胰管高压导致高脂血症性急性胰腺炎的发病机制  

The pathogenesis of hyperlipidemic acute pancreatitis caused by pancreatic duct hypertension

作　　者：冯佳晨 张平[1] FENG Jiachen;ZHANG Ping(First Department of Hepatopancreatobiliary Surgery,Center of General Surgery,The First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院普通外科中心-肝胆胰外一科,长春130021

出　　处：《临床肝胆病杂志》2024年第1期204-207,共4页Journal of Clinical Hepatology

摘　　要：高脂血症性急性胰腺炎与其他病因的急性胰腺炎相比,重症率更高,预后更难预测,发病机制复杂且不清晰。目前已知的发病机制可能与血清游离脂肪酸升高有关,但降低血脂的治疗方案并未降低本病的发病率。近期,胰管高压是急性胰腺炎重要的发病机制被进一步证实,而最新研究进展表明高脂血症可通过引起胰管增生、形成胆胰管汇合部蛋白栓、损伤胰管的分泌功能来导致胰管堵塞,胰管堵塞又可引起胰管高压。本文综述了高脂血症在导致胰管堵塞方面的最新研究和进展,并强调胰管高压是高脂血症性急性胰腺炎重要的发病机制之一,这将为研究高脂血症性急性胰腺炎的发病机制提供新的思路。Compared with acute pancreatitis caused by other factors,hyperlipidemic acute pancreatitis often has a higher rate of severe conditions,greater difficulties in predicting prognosis,and a more complex and unclear pathogenesis.At present,the pathogenesis of hyperlipidemic acute pancreatitis may be associated with the elevation of serum free fatty acids,but the lipidlowering treatment regimens do not reduce the incidence rate of this disease.Recent studies have further confirmed that pancreatic duct hypertension is an important pathogenesis of acute pancreatitis.The latest research advances have shown that hyperlipidemia can lead to pancreatic duct obstruction by causing pancreatic duct hyperplasia,forming protein embolism at the biliary-pancreatic junction,and damaging the secretory function of the pancreatic duct,while pancreatic duct obstruction can in turn cause pancreatic duct obstruction.This article reviews the latest research advances in hyperlipidemia in causing pancreatic duct obstruction and emphasizes that pancreatic duct hypertension is one of the important pathogeneses of hyperlipidemic acute pancreatitis,which will provide new ideas for exploring the pathogenesis of hyperlipidemic acute pancreatitis.

关 键 词：胰腺炎 胰管高压 高脂血症 

分 类 号：R589.2[医药卫生—内分泌] R576[医药卫生—内科学]