白藜芦醇对2型糖尿病患者肾功能及其危险因素影响的Meta分析  

Meta-analysis of Resveratrol on Renal Function and Related Risk Factors in Patients with Type 2 Diabetes Mellitus

作　　者：许丽丽 汤羽[2] 卢守燕[3] 赵娟[3] 陈婷 陈彩合 黄文辉[3] XU Lili;TANG Yu;LU Shouyan(First Clinical Medical College of Gansu University of Chinese Medicine(Gansu Provincial Hospital),Lanzhou,730000)

机构地区：[1]甘肃中医药大学第一临床医学院(甘肃省人民医院),兰州730000 [2]甘肃省人民医院检验科,兰州730000 [3]甘肃省人民医院肾内科,兰州730000

出　　处：《中国中西医结合肾病杂志》2023年第12期1077-1084,共8页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：甘肃省自然科学基金资助项目(No.20JR10RA398)。

摘　　要：目的:用Meta分析评价白藜芦醇对2型糖尿病(T2DM)患者肾功能及其血脂、血压、体重等危险因素的影响。方法:检索Pubmed、Web of Science、Embase、Medline、The Cochrane Library、VIP、CNKI数据库,筛选出2022年5月以前的相关文献。根据Cochrane系统评价手册评价各文献的研究质量,采用Review Manager 5.4软件对纳入文献的数据进行Meta分析。结果:共纳入7篇文献,实验组160例患者,对照组154例患者。Meta分析结果显示,白藜芦醇显著降低T2DM患者的血尿素氮(BUN)(P=0.001)和收缩压(P=0.000 8),对空腹血糖(FBG)(P=0.02)、胰岛素(P=0.02)、胰岛素抵抗指数(HOMA-IR)(P=0.03)亦有改善作用,但对血肌酐(Scr)(P=0.23)、糖化血红蛋白(HbA1c)(P=0.07)、舒张压(P=0.07)、体重(P=0.1)、体重指数(BMI)(P=0.11)及血脂(TG)(P=0.52)、LDL(P=0.29)、HDL(P=0.88)和胆固醇(TC)(P=0.13)的影响差异均无统计学意义。结论:白藜芦醇对2型糖尿病患者的肾功能及相关危险因素具有部分改善作用,但证据有限,需要更多的大样本多中心随机对照试验进一步证实。Objective:The effects of resveratrol on renal function and its risk factors including blood lipid,blood pressure,weight and other risk factors in patients with type 2 diabetes mellitus(T2DM)were evaluated by Meta-analysis.Methods:Pubmed,Web of Science,Embase,Medline,The Cochrane Library,VIP and CNKI databases were searched to screen out relevant literatures before May 2022.The quality of each study was evaluated according to the Cochrane Systematic Review Manual,and Review Manager 5.4 software was used to perform meta-analysis on the data of the included studies.Results:A total of 7 articles were included,including 160 patients in the experimental group and 154 patients in the control group.The results showed that resveratrol not only significantly decreased the blood urea nitrogen(BUN)(P=0.001)and systolic blood pressure(P=0.0008),but also improved fasting blood glucose(FBG)(P=0.02),insulin(P=0.02),insulin resistance index(HOMA-IR)(P=0.03)in patients with type 2 diabetes mellitus.However,resveratrol had no significant effects on blood creatinine(Scr)(P=0.23),glycosylated hemoglobin(HbA1c)(P=0.07),diastolic blood pressure(P=0.07),body weight(P=0.1),body mass index(BMI)(P=0.11),blood lipids(TG)(P=0.52),LDL(P=0.29)and HDL(P=0.88)and cholesterol(TC)(P=0.13).Conclusion:Resveratrol can partially improve renal function and its related risk factors in patients with type 2 diabetes mellitus,but the evidence is still limited.More large samples,multicenter randomized controlled trials are needed to investigate further.

关 键 词：白藜芦醇 2型糖尿病 肾功能 危险因素 META分析 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]