硫氧还蛋白还原酶结构与肿瘤治疗的研究进展  

Review on Progress of Thioredoxin Reductase Structure and Tumor Therapy

作　　者：堵忠颖 夏东方 高学云 DU Zhongying;XIA Dongfang;GAO Xueyun(Faculty of Environment and Life,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学环境与生命学部,北京100124

出　　处：《北京工业大学学报》2024年第2期246-260,共15页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(U2067214)。

摘　　要：硫氧还蛋白还原酶(thioredoxin reductase,TrxR)是硫氧还蛋白(thioredoxin,Trx)系统里主要的功能蛋白,在调节多种细胞氧化还原信号通路中起关键作用。近年来,TrxR/Trx被越来越多地认为是肿瘤发展的重要调节剂,因此靶向TrxR/Trx是一种很有前景的肿瘤治疗策略。该文对TrxR的结构特点、与肿瘤相关的生理功能、TrxR抑制剂进行综述,以对TrxR的研究提供参考。Thioredoxin reductase(TrxR)is a major functional protein in the thioredoxin system(Trx)and plays a key role in regulating various cellular redox signaling pathways.In recent years,TrxR/Trx has been increasingly recognized as an important regulator of tumor development,therefore,targeting TrxR/Trx is a promising tumor treatment strategy.In this paper,the structural characteristics,tumor-related physiological functions and inhibitors of TrxR were reviewed to provide references for the research of TrxR.

关 键 词：硫氧还蛋白还原酶 氧化还原平衡 蛋白结构与功能 肿瘤治疗 细胞凋亡 抑制剂 

分 类 号：U461[机械工程—车辆工程] TP308[交通运输工程—载运工具运用工程]