骨髓间充质干细胞来源外泌体对创伤性颅脑损伤的影响研究进展  

The research progress on the impact of bone marrow mesenchymal stem cell-derived extracellular vesicles on traumatic brain injury

作　　者：刘昊东 武泽军 赵君爽 胡钧涛[1,2] LIU Haodong;WU Zejun;ZHAO Junshuang;HU Juntao(Taihe Hospital Affiliate to Hubei Uni-versity of Medicine,Shiyan 442000,China)

机构地区：[1]湖北医药学院附属太和医院神经外科,十堰442000 [2]湖北医药学院 [3]锦州医科大学

出　　处：《中国神经精神疾病杂志》2023年第11期700-704,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：湖北省教育厅科学研究指导性项目(编号:B2022129);湖北医药学院人才启动金项目(编号:2018QDJZR15);湖北省卫生健康委员会指导项目(编号:WJ2019F055);十堰市科技局引导性项目(编号:22Y18)。

摘　　要：创伤性颅脑损伤(traumatic brain injury,TBI)是一种发病机制复杂的疾病,目前仍缺乏行之有效的治疗方法。研究证明,骨髓间充质干细胞来源的外泌体(bone marrow mesenchymal stem cell-derived extracellular vesicles,BMSC-EVs)通过减轻病灶处的神经炎症反应、促进神经血管再生,发挥其对TBI的治疗作用,但具体作用机制未完全明确。本文旨在探究BMSC-EVs治疗TBI的作用机制和研究进展,并初步探讨BMSC-EVs未来的研究方向及临床应用前景。Traumatic brain injury(TBI)is a multifaceted disease with a complex pathogenesis for which there are currently no effective therapeutic interventions.Research has shown that bone marrow mesenchymal stem cell-derived extracellular vesicles(BMSC-EVs)may play a therapeutic role in TBI.They attenuate neuroinflammatory responses at the site of the lesion and promote neurovascular regeneration.However,the exact mechanisms underlying their actions are not fully understood.This article aims to review the current state of research on the therapeutic mechanisms of BMSC-EVs in TBI.It also aims to discuss possible future research directions and potential clinical applications of BMSC-EVs.

关 键 词：创伤性颅脑损伤 神经炎症 神经修复 骨髓间充质干细胞 外泌体 微小RNA 

分 类 号：R651[医药卫生—外科学]