Parkin泛素化调节线粒体稳态在心血管疾病中的研究进展  

Research progress of Parkin protein regulating mitochondrial homeostasis through ubiquitination in cardiovascular diseases

作　　者：李珂娟 陈建淑 李勇男[2] 谢宜欣 卜佳乐 张小卫[1] LI Ke-juan;CHEN Jian-shu;LI Yong-nan;XIE Yi-xin;BU Jia-le;ZHANG Xiao-wei(Dept of Cardiovascular Diseases,the Second Hospital of Lanzhou University,Lanzhou 730000,China;Dept of Cardiothoracic Surgery,the Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院心血管内科,甘肃兰州730000 [2]兰州大学第二医院心胸外科,甘肃兰州730000

出　　处：《中国药理学通报》2024年第2期224-228,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 82060080);甘肃省科技厅项目(No 20YF3WA016,21JR11RA116);兰州市科技局项目(No 2019-RC36)。

摘　　要：线粒体不仅为细胞提供能量,还参与细胞钙稳态、细胞信息传递、细胞凋亡、细胞生长和分化等过程。因此,维持线粒体稳态对机体的正常生命活动至关重要。泛素化是一种蛋白质翻译后修饰方式,通过调节线粒体稳态过程进而参与细胞的多种生理病理过程。但目前还未对泛素化调节线粒体稳态的机制进行总结性阐述,特别是Parkin蛋白对心血管疾病影响的机制。该文主要通过对Parkin蛋白泛素化调节线粒体稳态的具体机制进行讨论,同时将线粒体稳态失衡对心血管疾病的影响进行综述,以期对心血管疾病的临床治疗提供潜在的治疗策略。In addition to providing energy for cells,mitochondria also participate in calcium homeostasis,cell information transfer,cell apoptosis,cell growth and differentiation.Therefore,maintaining mitochondrial homeostasis is very crucial for the body to carry out normal life activities.Ubiquitination,a post-translational modification of proteins,is involved in various physiological and pathological processes of cells by regulating mitochondrial homeostasis.However,the mechanism by which ubiquitination regulates mitochondrial homeostasis has not been summarized,especially the effect of Parkin protein on cardiovascular diseases.In this paper,the specific mechanism of mitochondrial homeostasis regulated by ubiquitination of Parkin protein is discussed,and the influence of mitochondrial homeostasis imbalance on cardiovascular diseases is reviewed,with a view to providing potential therapeutic strategies for the clinical treatment of cardiovascular diseases.

关 键 词：泛素化 线粒体动力学 线粒体自噬 PINK1/Parkin 高血压 冠心病 心力衰竭 心肌病 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学] R349.1R54R977.6