瑞马唑仑复合曲马多在膀胱镜相关手术中的应用研究  

Study on application of remimazolam combined with tramadol in cystoscopy related surgery

作　　者：杨廷[1] 吴金鹏 刘丽丽 刘凤 王亚洲[3] YANG Ting;WU Jin-peng;LIU Li-li(Pharmacy Department,Xuecheng District People's Hospital,Zaozhuang 277000,China)

机构地区：[1]枣庄市薛城区人民医院药剂科,277000 [2]枣庄市薛城区人民医院麻醉科,277000 [3]枣庄市薛城区人民医院科教科,277000 [4]山东健康集团枣庄中心医院急诊科,277000

出　　处：《中国现代药物应用》2023年第24期12-16,共5页Chinese Journal of Modern Drug Application

基　　金：受山东省医学会舒适化医疗-基层优化专项资金支持(项目编号:鲁医会(2022)93号)项目名称:瑞马唑仑复合曲马多在膀胱镜相关手术中的应用研究。

摘　　要：目的探讨瑞马唑仑复合曲马多在膀胱镜相关手术中的应用效果。方法120例行膀胱镜相关短小手术的患者,采用随机抽签法分为对照组和观察组,每组60例。对照组采用丙泊酚复合曲马多进行麻醉,观察组采用瑞马唑仑复合曲马多进行麻醉。比较两组患者麻醉药物起效时间、苏醒时间、镇静成功率、体动反应情况,不同时间点[麻醉前(T0)、睫毛反射消失(T1)、进镜时(T2)、操作至5 min时(T3)、退镜时(T4)、麻醉苏醒时(T5)]生命体征[心率(HR)、平均动脉压(MAP)、血氧饱和度(SpO_(2))],不良反应发生情况。结果两组麻醉药物起效时间、镇静成功率比较,差异无统计学意义(P>0.05);观察组苏醒时间(3.81±1.03)min短于对照组的(8.62±1.87)min,体动反应发生率3.33%低于对照组的15.00%,差异有统计学意义(P<0.05)。观察组T0、T1、T2、T3、T4、T5时MAP分别为(85.65±5.23)、(85.96±5.72)、(86.74±5.67)、(86.69±5.71)、(86.96±4.67)、(86.31±5.67)mm Hg(1 mm Hg=0.133 kPa),HR分别为(73.93±4.67)、(74.41±4.31)、(74.73±4.57)、(75.15±3.98)、(74.93±3.67)、(74.53±3.87)次/min,SpO_(2)分别为(97.15±1.23)%、(96.94±1.82)%、(96.74±1.17)%、(96.69±1.31)%、(96.76±1.37)%、(96.94±1.67)%;对照组T0、T1、T2、T3、T4、T5时MAP分别为(85.64±5.67)、(82.05±4.63)、(80.34±4.46)、(81.65±4.07)、(82.87±4.07)、(83.08±4.66)mm Hg,HR分别为(73.65±4.66)、(70.35±3.67)、(68.51±3.34)、(69.67±3.67)、(71.64±4.02)、(72.07±3.57)次/min,SpO_(2)分别为(97.64±1.66)%、(94.25±1.63)%、(93.04±1.06)%、(91.57±1.61)%、(93.64±1.07)%、(94.01±0.66)%。观察组T1、T2、T3、T4、T5时MAP、HR、SpO_(2)与T0时比较,差异无统计学意义(P>0.05);对照组T1、T2、T3、T4、T5时MAP、HR、SpO_(2)均明显低于T0时,差异有统计学意义(P<0.05);T0时,两组MAP、HR、SpO_(2)比较,差异无统计学意义(P>0.05);T1、T2、T3、T4、T5时,观察组MAP、HR、SpO_(2)均高于对照组,差异有统计学意义(P<0.05)�Objective To discuss the application effect of remimazolam combined with tramadol in cystoscopy related surgery.Methods A total of 120 patients undergoing minor surgeries related to cystoscopy were divided into a control group and an observation group according to random lottery method,with 60 cases in each group.The control group was anesthetized with propofol and tramadol,and the observation group was anesthetized with remimazolam and tramadol.Both groups were compared in terms of onset time of anesthetic drugs,recovery time,successful rate of sedation,body movement,vital signs[heart rate(HR),mean arterial pressure(MAP),blood oxygen saturation(SpO_(2))]at different time points[before anesthesia(T0),eyelash reflex disappearance(T1),endoscopic(T2),operation to 5 min(T3),endoscopic withdrawal(T4),recovery from anesthesia(T5)],and the occurrence of adverse reactions.In the observation group,MAP at T0,T1,T2,T3,T4 and T5 were(85.65±5.23),(85.96±5.72),(86.74±5.67),(86.69±5.71),(86.96±4.67)and(86.31±5.67)mm Hg(1 mm Hg=0.133 kPa),HR were(73.93±4.67),(74.41±4.31),(74.73±4.57),(75.15±3.98),(74.93±3.67)and (74.53±3.87) beats/min, SpO_(2) were (97.15±1.23) %, (96.94±1.82) %, (96.74±1.17) %, (96.69±1.31) %, (96.76±1.37) % and (96.94±1.67) %. In the control group, MAP at T0, T1, T2, T3, T4 and T5 were (85.64±5.67), (82.05±4.63), (80.34±4.46), (81.65±4.07), (82.87±4.07) and (83.08±4.66) mm Hg, HR were (73.65±4.66), (70.35±3.67), (68.51±3.34), (69.67±3.67), (71.64±4.02) and (72.07±3.57) beats/min, SpO_(2) were (97.64±1.66) %, (94.25±1.63) %, (93.04±1.06) %, (91.57±1.61) %, (93.64±1.07) % and (94.01±0.66) %. In the observation group, MAP, HR and SpO_(2) at T1, T2, T3, T4 and T5 were not significantly different from those at T0 (P > 0.05). In the control group, MAP, HR and SpO_(2) at T1, T2, T3, T4 and T5 were significantly lower than those at T0, and the differences were statistically significant (P<0.05). At T0, there was no statistically significant difference in MAP, HR and SpO_(2) between

关 键 词：瑞马唑仑 曲马多 静脉麻醉 膀胱镜相关手术 

分 类 号：R614[医药卫生—麻醉学]