TSH检测在孕前优生检查中的应用价值分析  

Analysis of the application value of TSH detection in prenatal eugenics examination

作　　者：林修 LIN Xiu(Minhou County Maternal and Child Health Hospital,Fuzhou 350100,China)

机构地区：[1]闽侯县妇幼保健院,350100

出　　处：《中国现代药物应用》2023年第24期95-99,共5页Chinese Journal of Modern Drug Application

摘　　要：目的 分析促甲状腺激素(TSH)检测在孕前优生检查中的应用价值。方法 100例接受优生优育免费筛查的育龄女性为研究对象,对其TSH实施检测,并借助酶联免疫吸附测定法(ELISA)检测甲状腺过氧化物酶抗体(TPOAb)。分析不同年龄段及不同体质量指数(BMI)育龄女性的TSH检测结果;分析TSH异常与TSH正常育龄女性的TPOAb检测结果。结果 100例育龄女性中, TSH异常6例,占比6.0%。20~29岁TSH异常率为5.4%, 30~39岁TSH异常率为4.8%, 40~45岁TSH异常率为20.0%。40~45岁为高峰。BMI<18.5 kg/m^(2)TSH异常率为100.0%, 18.5~23.9 kg/m^(2)TSH异常率为1.1%, 24.0~27.9 kg/m^(2)TSH异常率为100.0%,>28.0 kg/m^(2)TSH异常率为100.0%。育龄女性BMI过低或过高均可升高TSH异常率。6例TSH异常育龄女性中, 3例TSH<0.3 mU/L育龄女性中1例TPOAb阳性,占比33.3%;3例TSH>4.8 mU/L育龄女性中1例TPOAb阳性,占比33.3%;不同TSH异常育龄女性的TPOAb阳性率比较,差异无统计学意义(P>0.05)。TSH异常育龄女性的TPOAb阳性率为33.3%(2/6),高于TSH正常育龄女性的6.4%(6/94),差异具有统计学意义(P<0.05)。结论 TPOAb、肥胖、体重过高或过低、年龄大均与育龄女性TSH异常有关。Objective To analyze the application value of thyroid stimulating hormone(TSH)detection in prenatal eugenics examination.Methods 100 women of childbearing age who received free screening for eugenics were selected,and their TSH was detected.Their thyroid peroxidase antibody(TPOAb)was detected by enzyme-linked immunosorbent assay(ELISA).TSH test results of women of childbearing age at different ages,TSH test results of women of childbearing age at different body mass index(BMI),and TPOAb test results of women with abnormal TSH and normal TSH were analyzed.Results Among 100 women of childbearing age,6 cases(6.0%)had abnormal TSH.The rate of TSH abnormality was 5.4%in women aged 20-29 years old,4.8%in women aged 30-39 years old age group,and 20.0%in women aged 40-45 years old.The peak was at the age of 40-45 years.The rate of TSH abnormality was 100.0%in women with BMI<18.5 kg/m^(2),1.1%in women with 18.5-23.9 kg/m^(2),100.0%in women with 24.0-27.9 kg/m^(2),and 100.0%in women with>28.0 kg/m^(2).Both low and high BMI in women of childbearing age could increase the rate of TSH abnormality.Among the 6 women of childbearing age with abnormal TSH,1 in 3 women of childbearing age with TSH<0.3 mU/L was TPOAb positive,accounting for 33.3%;1 in 3 women of childbearing age with TSH>4.8 mU/L was TPOAb positive,accounting for 33.3%.There was no statistically significant difference in the positive rate of TPOAb among women of childbearing age with different TSH abnormalities(P>0.05).The positive rate of TPOAb in women with abnormal TSH was 33.3%(2/6),which was higher than that of 6.4%(6/94)in women with normal TSH,and the difference was statistically significant(P<0.05).Conclusion TPOAb,obesity,overweight or underweight,and older age are all associated with abnormal TSH in women of childbearing age.

关 键 词：优生检查 促甲状腺激素 孕前 甲状腺过氧化物酶抗体 

分 类 号：R169.1[医药卫生—公共卫生与预防医学] R446.1