左氧氟沙星治疗耐多药肺结核的效果和患者不良反应观察  

Effect and Adverse Reactions of Levofloxacin in the Treatment of Multidrug-resistant Tuberculosis

作　　者：鲁晶晶 LU Jingjing(Diaobingshan Center for Disease Control and Prevention,Diaobingshan 112700,China)

机构地区：[1]调兵山市疾病预防控制中心,调兵山112700

出　　处：《中国医药指南》2024年第3期74-76,共3页Guide of China Medicine

摘　　要：目的观察左氧氟沙星治疗耐多药肺结核的效果和患者不良反应。方法2018年1月至2020年12月搜集102例耐多药肺结核病例,计算机随机分组,对照组、观察组每组51例。对照组男30例,女21例,年龄(55.74±2.02)岁,病程(5.05±0.23)年;观察组男28例,女23例,年龄(55.76±2.03)岁,病程(5.11±0.25)年。对照组患者采取常规3HRZE/6HRE方案治疗,观察组在上述基础上联合左氧氟沙星治疗。观察两组用药安全。结果两组比较,观察组临床疗效(92.16%)更高,P<0.05,χ^(2)=5.718,有统计学意义。治疗前,观察组患者IL-12水平(45.57±4.55)ng/L,对照组患者IL-12水平(45.67±4.51)ng/L,P>0.05,t=0.111,组间差异无统计学意义;观察组患者IFN-γ水平(11.90±2.34)ng/L,对照组患者IFN-γ水平(11.94±2.37)ng/L,P>0.05,t=0.086,组间差异无统计学意义。治疗后,观察组患者IL-12水平(61.11±4.37)ng/L,对照组患者IL-12水平(55.93±4.01)ng/L,t=6.237,P<0.05,有统计学意义;观察组患者IFN-γ水平(20.00±2.37)ng/L,对照组患者IFN-γ水平(15.87±2.49)ng/L,t=8.580,P<0.05,有统计学意义。观察组患者不良反应发生比率11.76%,对照组患者不良反应发生比率5.88%,χ^(2)=1.097,P>0.05,无统计学意义。观察组患者治疗后12个月后转阴人数为45例,转阴率为88.24%,而对照组治疗12个月后转阴人数为36例,转阴率为70.59%,对照组各个时间段转阴率均低于观察组,总转阴率比较存在统计学差异,P<0.05。结论左氧氟沙星治疗耐多药肺结核有助于提高临床疗效及免疫功能,未明显增加不良反应,安全性良好。Objective To observe the efficacy and adverse reactions of levofloxacin in the treatment of multidrug-resistant pulmonary tuberculosis.Methods One hundred and two cases of MDR-TB were collected from January 2018 to December 2020,and randomly divided into control group and observation group with 51 cases in each group.There were 30 males and 21 females in the control group,aged(55.74±2.02)years,with a disease course of(5.05±0.23)years;There were 28 males and 23 females in the observation group,aged(55.76±2.03)years,with a disease course of(5.11±0.25)years.The control group patients were treated with a conventional 3HRZE/6HRE regimen,while the observation group was treated with a combination of levofloxacin.Observe the safety of two groups of medication.Results The clinical efficacy of the observation group(92.16%)higher than that of the control group,with P<0.05,χ^(2)=5.718,statistically significant.Before treatment,the IL-12 levels in the observation group were(45.57±4.55)ng/L,while those in the control group were(45.67±4.51)ng/L,P>0.05,t=0.111,and there was no statistically significant difference between the groups;Observation group patient IFN-γlevel(11.90±2.34)ng/L,IFN-γlevel in control group patients was(11.94±2.37)ng/L,P>0.05,t=0.086,and there was no statistically significant difference between the groups.After treatment,the IL-12 levels in the observation group was(61.11±4.37)ng/L,while those in the control group was(55.93±4.01)ng/L,P<0.05,t=6.237,with statistical significance;Observation group patient IFN-γlevel(20.00±2.37)ng/L,IFN-γin control group patients was(15.87±2.49)ng/L,P<0.05,t=8.580,statistically significant.The incidence of adverse reactions in the observation group was 11.76%,while the incidence of adverse reactions in the control group was 5.88%,with P>0.05,χ^(2)=1.097,no statistically significant.After 12 months of treatment,45 patients in the observation group turned negative,with a conversion rate of 88.24%,while 36 patients in the control group turned negative,with a conv

关 键 词：左氧氟沙星 耐多药肺结核 效果 不良反应 

分 类 号：R521[医药卫生—内科学]