丹栀逍遥散加减方对精神分裂症患者高催乳素血症的影响研究  

Effect of Modified Danzhi Xiaoyao Powder on hyperprolactinemia in schizophrenia patients

作　　者：许桦[1,2] 邢梦娟 孙扬[3] 潘晓鸥 陆颖[1,2] 吴海苏[3] 朱丽萍[1,2] 何永光 XU Hua;XING Mengjuan;SUN Yang;PAN Xiaoou;LU Ying;WU Haisu;ZHU Liping;HE Yongguang(Department of integrated Chinese and Western medicine,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108;Shanghai Institute of Mental Diseases of Traditional Chinese Medicine,Shanghai 201108;Department of psychiatry,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108)

机构地区：[1]上海交通大学医学院附属精神卫生中心中西医结合科,上海201108 [2]上海市中医神志病研究所,上海201108 [3]上海交通大学医学院附属精神卫生中心精神科,上海201108

出　　处：《河北中医》2024年第1期56-60,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：上海市科学技术委员会科研计划项目(编号:17401932600,16401934700,10DZ1973300);上海市卫生健康委员会中医重点专科培育项目(编号:AB83180002019021)。

摘　　要：目的观察丹栀逍遥散加减方对精神分裂症患者高催乳素水平的影响。方法将118例精神分裂症并发有高催乳血症患者按照随机数字表法分为2组,2组均常规给予抗精神分裂症药物治疗,治疗组56例予丹栀逍遥散加减方治疗,对照组62例予安慰剂治疗。2组均治疗12周后。比较2组治疗前及治疗4、12周血清催乳素、精神症状[采用阳性和阴性症状量表(PANSS)评分进行评价]及生活质量[采用精神分裂症患者生活质量量表(SQLS)进行评价,包括心理社会、动机/精力、症状/副反应3个方面]变化情况,统计分析治疗组治疗12周后血清催乳素水平与PANSS评分、SQLS评分之间的相关性。结果与本组治疗前比较,治疗组治疗4、12周血清催乳素水平均降低(P<0.05),且治疗组治疗4、12周血清催乳素水平均低于对照组同期(P<0.05),但对照组治疗4、12周血清催乳素水平与治疗前比较差异均无统计学意义(P>0.05)。2组治疗4、12周PANSS评分与本组治疗前比较及组间比较差异均无统计学意义(P>0.05)。与本组治疗前比较,治疗组治疗4、12周SQLS心理社会、动机/精力、症状/副反应评分及总分均降低(P<0.05),且治疗组治疗4、12周SQLS心理社会、动机/精力、症状/副反应评分及总分均低于对照组同期(P<0.05),但对照组治疗4、12周SQLS心理社会、动机/精力、症状/副反应评分及总分与治疗前比较差异均无统计学意义(P>0.05)。经Pearson相关性分析显示,治疗组治疗12周血清催乳素水平与SQSL症状/副反应评分及总分存在正相关性(r=0.259,P=0.005;r=0.263,P=0.004)。结论丹栀逍遥散加减方治疗精神分裂症患者高催乳素血症临床疗效确切,可有效降低患者血清催乳素水平,提高患者生活质量,是一种颇具治疗效应的临床辅助治疗手段。Objective To evaluate the effect of modified Danzhi Xiaoyao Powder on hyperprolactinemia in schizophrenia patients.Methods Totally 118 patients with schizophrenia were randomly assigned into a control group(n=62)and a treatment group(n=56).All patients were managed by antipsychotics,and the treatment group was treated with modified Danzhi Xiaoyao Powder,while the control group was treated with placebo,the treatment was performed for 12 weeks for statistical efficacy.Before treatment and after 4 and 12 weeks of treatment,the positive and negative symptom scale(PANSS)scores were performed to evaluate serum prolactin and psychiatric symptoms.The Schizophrenia Quality of Life Scale(SQLS)involving psychosocial,motivation/energy,symptoms/side-effects three subscales was conducted to assess the quality of life.After 12 weeks of treatment,the correlation between serum prolactin level and PANSS score and SQLS score in the treatment group was statistically analyzed.Results After treatment,the levels of 4-week and 12-week serum prolactin in the treatment group were significantly decreased(P<0.05),and which were significantly lower in the treatment group than the control group(P<0.05),but there was no significant difference in serum prolactin between the levels of 4-week and 12-week and that before treatment in the control group(P>0.05).There was no significant difference in PANSS score between the levels of 4-week and 12-week and that before treatment in the both groups(P>0.05).Compared with before treatment,the each dimension scores and total score of 4-week and 12-week SQLS in the treatment group were significantly decreased(P<0.05),and the scores in the treatment group were significantly lower than those in the control group(P<0.05).However,there was no significant difference in the each dimension scores and total score of 4-week and 12-week SQLS in the control group compared with those before treatment(P>0.05).Pearson correlation analysis showed that there was a positive correlation between 12-week serum prolactin level

关 键 词：精神分裂症 催乳素 中药疗法 丹栀逍遥散 

分 类 号：R289.6[医药卫生—方剂学]