聚乙烯亚胺修饰化二硫化钼光控纳米粒在阿替洛尔经皮递药中的应用  

NIR-controlled transdermal delivery of atenolol based on polyethyleneimine-modified MoS2 nanoparticles

作　　者：崔艺舰 张凯 乔天琪 刘晓畅 CUI Yijian;ZHANG Kai;QIAO Tianqi;LIU Xiaochang(Postgraduate of Grade 2021,Shenyang Medical College,Shenyang 111034,China;College of Science and Technology,Hebei Agricultural University;Graduate School,Hebei North University;School of Pharmacy,Shenyang Medical College;Key Laboratory of Research on Pathogenesis of Allergen Provoked Allergic Disease in Liaoning Province,Shenyang Medical College)

机构地区：[1]沈阳医学院基础医学院,辽宁沈阳110034 [2]河北农业大学理工学院 [3]河北北方学院研究生院 [4]沈阳医学院药学院 [5]沈阳医学院辽宁省过敏性疾病过敏原致病机制研究重点实验室

出　　处：《沈阳医学院学报》2024年第1期11-17,共7页Journal of Shenyang Medical College

基　　金：辽宁省自然科学基金(No.2022-MS-410);河北省自然科学基金青年科学基金项目(No.H2021204006)。

摘　　要：目的:以阿替洛尔作为模型药物,旨在开发一种基于聚乙烯亚胺修饰的二硫化钼纳米粒(polyethyleneimine-modified Mo S2nanoparticles,PEI-Mo S2NPs)的近红外激光控释的经皮递药系统(transdermal drug delivery system,TDDS)。方法:通过一步水热合成法制备3D花瓣状结构的PEI-Mo S2NPs,并通过衰减全反射傅里叶变换红外光谱、X射线衍射分析、扫描电子显微镜和透射电子显微镜对其进行结构表征。通过体外药物释放实验和体外透皮实验研究PEI-Mo S2NPs的控释能力。结果:PEI-Mo S2NPs具有良好的药物负载效率(53.86%)和较高的光热转换能力。近红外激光刺激使阿替洛尔的释放增加了1.56倍。结论:近红外激光可用于控制PEI-Mo S2NPs中药物的释放,促进药物的经皮渗透。Objective:Using atenolol as a model drug,the aim of this study was to develop a sustained and controlled transdermal drug delivery system(TDDS)based on polyethyleneimine-modified MoS2 nanoparticles(PEI-MoS2 NPs)that were responsive to near infrared(NIR)laser irradiation.Methods:The three-dimensional flower-like PEI-MoS2 NPs were successfully synthesized and further characterized by attenuated total reflection Fourier transform infrared spectroscopy,X-ray diffraction measurements,scanning electron microscopy,and transmission electron microscopy.The controlled release capacity of PEI-MoS2 NPs was examined using in vitro drug release and skin penetration experiments.Results:The PEI-MoS2 NPs exhibited a drug loading efficiency of 53.86%and high photothermal conversion ability.Moreover,the release of atenolol was enhanced by NIR stimulation with an enhancement ratio of 1.56.Conclusion:NIR-controlled PEI-MoS2 NPs was essential for the control and sustained release of drugs in TDDS.

关 键 词：二硫化钼纳米粒 经皮递药系统 控释系统 近红外激光 聚乙烯亚胺 

分 类 号：R96[医药卫生—药理学]