小儿紫癜疹消颗粒治疗过敏性紫癜临床观察  

Xiao'er Zidian Zhenxiao Granules in the Treatment of Henoch-Schonlein Purpura

作　　者：朱浩宇[1] 薛娇娇 郭黎明 ZHU Haoyu;XUE Jiaojiao;GUO Liming(Department of Internal Medicine,Pediatrics Medical Center,Affiliated Hospital of Changchun University of Chinese Medicine,Jilin Province,Changchun 130021,China;Graduate School,Changchun University of Chinese Medicine,Jilin Province,Changchun 130117,China)

机构地区：[1]长春中医药大学附属医院儿童诊疗中心内二科,吉林长春130021 [2]长春中医药大学研究生院,吉林长春130117

出　　处：《中国中医药现代远程教育》2024年第4期114-117,共4页Chinese Medicine Modern Distance Education of China

基　　金：吉林省自然科学基金【No.20190201146JC】;吉林省中医药科技项目【No.2021059,2023014】。

摘　　要：目的 分析过敏性紫癜(HSP)患儿的临床特征及观察小儿紫癜疹消颗粒的临床疗效。方法 选择2020年1月—2021年1月就诊于长春中医药大学附属医院(吉林省中医院)儿童诊疗中心门诊的HSP患儿60例作为研究对象,按随机数字表法分为对照组和治疗组,每组30例,分别给予小儿紫癜疹消颗粒和银翘散口服,疗程7 d。调查HSP患儿一般情况、血常规等炎症指标以及过敏原。结果 患儿男女比例为1.14∶1,年龄5~10岁,发病多见于1、2和10、11、12月份,一般炎症指标血常规、降钙素、抗O均有所上升,部分患者腺病毒、人呼吸道合胞病毒等抗体阳性,血清IgA、补体C3水平明显升高,80%的HSP患儿过敏原呈阳性。治疗后,治疗组的总有效率为93.33%(28/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);且治疗组的中医证候积分较对照组明显下降(P<0.05)。结论 关于HSP,男孩发病略多于女孩,5~10岁为主,秋冬季多见。患儿炎症指标升高,可伴有病毒、肺炎支原体衣原体感染,较多患儿过敏原阳性,急性期存在体液免疫紊乱。临床证实,小儿紫癜疹消颗粒治疗HSP效果显著。Objective To analyze the clinical features of children with Henoch-Schonlein purpura(HSP) and observe the clinical efficacy of Xiao'er Zidian Zhenxiao granules in children.Methods A total of 60 children with HSP who were admitted to Pediatrics Medical Center of Affiliated Hospital of Changchun University of Chinese Medicine(Jilin Province Hospital of Traditional Chinese Medicine) from January 2020 to January 2021 were selected as the study objects,and were divided into control group and treatment group according to random number table method,with 30 cases in each group.The patients were given Xiao'er Zidian Zhenxiao granules and Yinqiao powder orally for 7 days respectively.The general condition,blood routine and other inflammatory indicators and allergens of HSP children were investigated.Results The male to female ratio of the children was 1.14∶1,and the age was 5 to 10 years old.The incidence was most common in the months of January,February,October,November,and December.General inflammatory indicators such as blood routine,calcitonin,and anti-O were increased,some patients were positive for antibodies such as adenovirus and human respiratory syncytial virus,serum IgA and complement C3 levels were significantly increased,and 80% of HSP children were positive for allergens.After treatment,the total effective rate of the treatment group was 93.33%(28/30),which was higher than that of the control group(73.33%,22/30),and the difference was statistically significant(P<0.05).The TCM syndrome score of the treatment group was significantly lower than that of the control group(P<0.05).Conclusion About HSP,the incidence of boys slightly more than girls,5-10 years old,more common in autumn and winter.Children with elevated inflammatory indicators may be accompanied by virus and mycoplasma pneumoniae chlamydia infection,more children are allergen positive,and humoral immunity disorders exist in the acute stage.Clinical results showed that the effect of Xiao'er Zidian Zhenxiao granules on HSP was significant.

关 键 词：血证 过敏性紫癜 临床特征 小儿紫癜疹消颗粒 儿科 

分 类 号：R272[医药卫生—中医儿科学]