白长川教授“滞伤脾胃”理论在胃癌癌前病变中的临床应用  

Clinical application of Professor Bai Changchuan’s theory of"stagnation injury of spleen and stomach"in precancerous lesions of gastric cancer

作　　者：胡欣[1] 杨洋[2] 胡旭阳 白长川 HU Xin;YANG Yang;HU Xuyang;BAI Changchuan(Department of Oncology,Dalian Hospital of Traditional Chinese Medicine,Liaoning,Dalian 116001,China;Institute(College)of Integrative Medicine,Dalian Medical University,Liaoning,Dalian 116000,China)

机构地区：[1]辽宁省大连市中医医院肿瘤科,辽宁大连116001 [2]大连医科大学中西医结合研究院,辽宁大连116000

出　　处：《中国医药科学》2023年第24期70-73,共4页China Medicine And Pharmacy

基　　金：辽宁省大连市中医药医学科学研究计划项目(20Z11004)。

摘　　要：目的 应用白长川教授“滞伤脾胃”理论治疗胃癌癌前病变,总结疗效。方法 选取2020年1月至2021年10月大连市中医医院内科门诊37例胃癌癌前病变病例,采用随机数表法分为对照组和治疗组,治疗组用运脾方治疗,对照组给予西医综合治疗,给予大连市中医医院现有的叶酸、莫沙必利,有幽门螺杆菌阳性的给予对抗治疗;观察治疗前后中医症状评分、肿瘤标志物评分以及电镜下肠化逆转率变化。结果 两组中医症状评分比较,治疗组各项评分均明显优于对照组,差异有统计学意义(P <0.05)。治疗后,治疗组完全缓解患者数量明显增多,肠化逆转率明显高于对照组,差异有统计学意义(P <0.05)。两组实验室检查治疗前后比较,治疗组癌胚抗原(CEA)及糖类抗原72-4(CA72-4)明显低于对照组,差异有统计学意义(P <0.05)。两组均未出现严重不良反应,治疗后复查血常规、肝肾功能均显示无异常。结论 在白长川教授“滞伤脾胃”理论指导下,用运脾方治疗胃癌癌前病变,能有效化解患者的胃痛、胃胀、纳呆、寐欠安等症状,逆转胃癌癌前病变向胃癌转化的趋势,通过研究,“滞伤脾胃”理论治疗胃癌癌前病变是有效的,临床切实可行。Objective To apply Professor Bai Changchuan’s theory of"stagnation injury of spleen and stomach"to treat precancerous lesions of gastric cancer and summarize the treatment effect.Methods A total of 37 patients with precancerous lesions of gastric cancer who visited the Internal Medicine Clinic of Dalian Hospital of Traditional Chinese Medicine from January 2020 to October 2021 were randomly divided into the control group and the treatment group.The treatment group was treated with Yunpi prescription,while the control group was treated with comprehensive western medicine,i.e.,the existing folic acid and mosapride in our hospital.Those with Helicobacter pylori positive were given antagonistic treatment.The changes of TCM syndrome score,tumor marker score and intestinal metaplasia reversal rate under electron microscope were observed before and after treatment.Results The TCM symptom score in the treatment group was significantly better than that in the control group,with statistically significant difference(P<0.05).After treatment,the number of patients with complete remission in the treatment group significantly increased,and the reversal rate of intestinal metaplasia was significantly higher than that in the control group,with a statistically significant difference(P<0.05).The data of carcino-embryonic antigen(CEA)and carbohydrate antigen 72-4(CA72-4)in the treatment group were significantly lower than those in the control group before and after treatment(P<0.05).There were no serious adverse reactions in the two groups,and blood routine and liver and kidney function showed no abnormality after treatment.Conclusion Under the guidance of Professor Bai Changchuan’s theory of"stagnation injury of spleen and stomach",Yunpi prescription in treating precancerous lesions of gastric cancer can effectively relieve the symptoms of stomach pain,bloating,decreased appetite and insomnia, and reverse the transformation trend of precancerous lesions of gastric cancer to gastric cancer. The research found that the theory of

关 键 词：“滞伤脾胃”理论 运脾方 胃癌癌前病变 预防 

分 类 号：R273[医药卫生—中西医结合]