69例疣状表皮痣的临床、病理及疗效分析  

作　　者：陈文颖 乐张慧 刘冬梅 

机构地区：[1]浙江省金华市第五医院,321000 [2]中南大学湘雅三医院,410000

出　　处：《浙江临床医学》2023年第12期1824-1826,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨疣状表皮痣的临床、病理及治疗方法。方法回顾分析69例疣状表皮痣患者的临床、病理和疗效资料。结果69例患者中男35例,女34例,平均发病年龄(2.80±3.68)岁,包括局限型65例、炎性线状型3例和泛发型1例。皮损主要表现为沿Blaschko线分布疣状丘疹及斑块,并发基底细胞癌1例,并发原位鳞状细胞癌1例。组织病理表现包括角化过度、棘层肥厚、乳头瘤样增生、角化不全、淋巴细胞浸润、基底层色素增加、毛细血管扩张、假性角囊肿、表皮松解角化过度等。结论采用手术治疗疗效确切,CO_(2)激光、维甲酸、糖皮质激素乳膏等治疗可作为辅助治疗手段以改善患者生活质量。Objective To investigate the clinical features,pathological features and prognosis of verrucous epidermal nevus(VEN).Methods The clinical date of 69 cases with VEN were collected in this retrospective analysis.Results A total of 35 male and 34 females were included,with an average onset age of(2.80±3.68)years old.The VEN cases in this study mainly presented as verrucous papules and plaques distributed along Blaschko line,with 65 cases were classified as localized type,3 cases as inflammatory linear type and 1 case as generalized type.Among them,1 case had a concomitant basal cell carcinoma and 1 case had squamous cell carcinoma in situ.The pathological findings include hyperkeratosis,acanthosis,papillomatous hyperplasia,dyskeratosis,lymphocy te infiltration,basal pigment increase,telangiectasia,pseudokeratocyst,epidermolysis and hyperkeratosis.Conclusion Surgical resection is effective in treating VEN.CO_(2)laser treatment,retinoic acid,glucocorticoid and other treatments serve as adjunctive therapy to improve the quality of life of patients.

关 键 词：疣状表皮痣 临床表现 组织病理 治疗 

分 类 号：R758.51[医药卫生—皮肤病学与性病学]