基于生/醋大黄的大承气汤对实热壅滞证胎粪性腹膜炎小鼠血清ET、NO和TNF-α的影响  

The Effects of Dachengqi Tang Based on Raw Rhubarb and Vinegar Rhubarb on Serum ET,NO and TNF-α in Mice with Faecal Peritonitis

作　　者：陆景荣 陆梅元 曾海生[3] 马秀梅 陈勇[4] 赵凤仙 陈宏夏 LU Jingrong;LU Meiyuan;ZENG Haisheng;MA Xiumei;CHEN Yong;ZHAO Fengxian;CHEN Hongxia(Guangxi International Zhuang Medicine Hospital,Nanning 530201,China;Guangxi Food and Drug Evaluation&Inspection Center,Nanning 530029,China;Affiliated Hospital of Youjiang Medical University for Nationalites,Baise 533000,China;Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西国际壮医医院,广西南宁530201 [2]广西壮族自治区食品药品审评查验中心,广西南宁530029 [3]右江民族医学院附属医院,广西百色533000 [4]广西中医药大学,广西南宁530200

出　　处：《西部中医药》2024年第1期5-8,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81360524);国家中医药管理局科研三级实验室中(壮)药化学与质量分析实验室(国中医药发2009[21]号);2019年度广西高校中青年教师科研基础能力提升项目(2019KY0341);2019年广西中医药大学青年基金项目(2019QN036)。

摘　　要：目的:研究基于生/醋大黄的大承气汤对胎粪性腹膜炎(faecal peritonitis with excessive heat stagnation,ABP)小鼠血清内毒素(endotoxin,ET)、一氧化氮(nitric oxide,NO)和肿瘤坏死因子α(tumor necrosis factor α,TNF-α)的影响。方法:将105只昆明种小鼠按随机数字表法分为生/醋大黄炮制品的大承气汤组(6、10 g/kg)、阳性对照组、空白对照组及模型组,按容积20 mL/kg剂量给药后测定各组小鼠血清ET、NO和TNF-α含量。结果:生/醋大黄炮制品的大承气汤组均能增加实热壅滞证ABP小鼠血清NO含量,降低小鼠血清ET和TNF-α含量。结论:生/醋大黄炮制品的大承气汤对ABP小鼠血清ET、NO和TNF-α含量的影响可能与生/醋大黄炮制方法以及其配伍的厚朴、枳实和芒硝有关。Objective:To investigate the influene of Dachengqi Tang based on raw rhubarb and vinegar rhubarb on serum ET,NO and TNF-αin mice with faecal peritonitis with excessive heat stagnation(ABP).Methods:All 105 Kunming mice were randomized into Dachengqi Tang groups of raw rhubarb and vinegar rhubarb(6 and 10 g/kg),positive control group,blank control group and the model group,dosed at 20 mL/kg by volume,to detect the contents of serum ET,NO and TNF-αin mice.Results:Dachengqi Tang groups of raw rhubarb and vinegar rhubarb could increase the contents of NO in ABP mice,decrease the contents of ET and TNF-α.Conclusion:The influence of Dachengqi Tang based on raw rhubarb and vinegar rhubarb on the contents of serum ET,NO and TNF-αin ABP mice might be related to the processings of raw and vinegar products and its combination with Houbo(Magnoliae officinalis cortex),Zhishi(Aurantii fructus immaturus)and Mangxiao(Natrii sulfas).

关 键 词：胎粪性腹膜炎 大承气汤 内毒素 一氧化氮 肿瘤坏死因子Α 

分 类 号：R585.5[医药卫生—内分泌]