血清载脂蛋白水平与突发性聋听力预后的相关性研究  

Correlation between Serum Apolipoprotein Level and Hearing Prognosis in Patients with Sudden Sensorineural Hearing Loss

作　　者：邹新博 唐旭霞[1] 吕臻一 何晓 ZOU Xinbo;TANG Xuxia;LV Zhenyi;HE Xiao(Department of Otolaryngology,First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang,310000;First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310000)

机构地区：[1]浙江中医药大学附属第一医院耳鼻咽喉科,杭州310000 [2]浙江中医药大学附属第一临床医学院,杭州310000

出　　处：《中华耳科学杂志》2023年第5期632-638,共7页Chinese Journal of Otology

基　　金：浙江省医药卫生科技计划资助项目针灸在前庭康复中的应用机制及疗效研究(2019RC060)。

摘　　要：目的探讨血清载脂蛋白水平对突发性聋患者听力预后的影响。方法回顾性分析210例突发性聋患者的临床资料,采用t检验、方差分析、卡方检验及多元Logistic统计方法,分析性别、是否伴有高血压、是否伴有糖尿病、听力曲线类型、听力损失程度的载脂蛋白A(Apolipoprotein A,ApoA),载脂蛋白B(Bpolipoprotein B,ApoB)以及ApoA/ApoB突聋患者水平以及临床疗效;以及不同临床特征的患者及ApoA、ApoB、ApoA/ApoB的血脂浓度对突聋患者临床预后的影响。结果性别分组ApoA(P=0.009),ApoA/ApoB(P=0.006),是否伴有高血压ApoA(P=0.042)差异有统计学意义;ApoA的均值在低频型、高频型、平坦型、全聋型患者的变化趋势为逐渐降低,ApoB、ApoA/ApoB的均值在低频型、高频型、平坦型、全聋型患者的变化趋势是逐渐升高;是否伴有高血压是突发性聋预后的危险因素。结论血脂ApoA、ApoB、ApoA/ApoB可能与突发性聋的预后无关,是否伴有高血压可能与突发性聋的预后的有关。Objective To investigate the influence of serum apolipoprotein level on hearing prognosis in patients with sudden sensorineural hearing loss.Methods Clinical data from 210 patients with sudden sensorineural hearing loss were retrospectively analyzed by t test,analysis of variance,Chi-square test and multivariate logistic regression,including gender,hypertension,diabetes,pattern of audiogram,ApoA,ApoB,ApoA/ApoB severity of hearing loss and treatment outcomes,with a focus on the association between levels of ApoA,ApoB,ApoA/ApoB and clinical characteristics as well as prognosis on hearing.Results Levels of ApoA and ApoA/ApoB were different between male and female patients(P=0.009 and P=0.006,respectively),and levels of ApoA were different between patients with and without hypertension(P=0.042).Levels of ApoA decreased in patients with low frequency,high frequency,flat or total deafness,while the level of ApoB and ApoA/ApoB increased in the same order.Hypertension was correlated with worse prognosis.Conclusion Serum levels of ApoA,ApoB and ApoA/ApoB may not be associated with the prognosis in sudden deafness,while hypertension appears to be a risk factor for unfavorable prognosis.

关 键 词：突发性聋、ApoA APOB ApoA/ApoB 

分 类 号：R764[医药卫生—耳鼻咽喉科]