儿童消化性溃疡临床特征及危险因素分析  

Clinical Features and Risk Factors of Pediatric Peptic Ulcer

作　　者：甘霖 李密 GAN Lin;LI Mi(Department of Pediatrics,The First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院儿科,河南南阳473000

出　　处：《中国烧伤创疡杂志》2024年第1期58-61,73,共5页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的分析儿童消化性溃疡的临床特征及相关危险因素。方法选取2020年3月至2023年3月南阳医学高等专科学校第一附属医院收治的260例消化性溃疡患儿(设为溃疡组),以及260名健康儿童(设为健康组)作为研究对象,收集研究对象性别、年龄、家族史、饮食喜好以及患儿临床症状(呕吐、恶心、反酸、嗳气等)及体征(上腹压痛等)等情况,分析儿童消化性溃疡的临床特征,并采用多因素Logistic回归分析儿童消化性溃疡的相关危险因素。结果儿童消化性溃疡患儿中男性(8423%)多于女性(1577%),年龄以学龄期儿童(4692%)和青春期儿童(4077%)为主,溃疡类型以十二指肠溃疡(7115%)和单发溃疡(7269%)为主,主要临床表现为腹痛(7115%)、呕吐(6308%)和黑便(4885%),且腹痛部位主要为剑突下、脐周和上腹部,其中仅2212%表现为与进食相关。多因素Logistic回归分析结果显示,有家族史、喜好冷食、喜好酸辣、经常吃外卖、幽门螺杆菌感染、心理障碍、家庭不和睦、住校/小餐桌是儿童消化性溃疡的独立危险因素(95%CI为1848~32710、1040~3659、1334~11937、1182~11257、1499~9424、1935~20817、1188~6046、1178~4867,P=0005、0037、0013、0024、0004、0002、0017、0015)。结论儿童消化性溃疡以学龄期和青春期男性儿童为主,溃疡类型主要为十二指肠溃疡,临床表现主要为腹痛、呕吐和黑便;有家族史、喜好冷食、喜好酸辣、经常吃外卖、幽门螺杆菌感染、心理障碍、家庭不和睦、住校/小餐桌是儿童消化性溃疡的独立危险因素。Objective To analyze the clinical features and risk factors for peptic ulcers in children.Methods 260 children with peptic ulcers,admitted to The First Affiliated Hospital of Nanyang Medical College between March 2020 and March 2023,were selected as research subjects,being set as the ulcer group.Meanwhile,260 healthy children were chosen to be set as the healthy group.Data of these research subjects,including sex,age,family history,dietary prefer-ences,clinical symptoms(vomiting,nausea,acid reflux,belching,etc),and physical signs(upper abdominal tender-ness,etc),were collected to analyze the clinical features of children with peptic ulcer,and multivariate Logistic regression analysis was conducted to analyze the risk factors for peptic ulcer in children.Results There were more males(8423%)than females(1577%)in children with peptic ulcer,mainly school-age children(4692%)and adolescent children(4077%).Duodenal ulcers(7115%)and single ulcers(7269%)were the main types of ulcers.The main clinical features of peptic ulcers were abdominal pain(7115%),vomiting(6308%),and black stool(4885%),and the abdominal pain mainly located in subxiphoid,peri-umbilicus,and upper abdomen,of which only 2212%was in relation to food intake.The results of multivariate Logistic regression analysis showed that family history,cold food preference,hot and sour taste preference,frequent takeaways diet,Helicobacter pylori infection,psychological disorder,family disharmony,and boarding in at the school or dining at small dining tables were the independent risk factors for pediatric peptic ulcer(95%CI:1848-32710,1040-3659,1334-11937,1182-11257,1499-9424,1935-20817,1188-6046 and 1178-4867,P=0005,0037,0013,0024,0004,0002,0017 and 0015).Conclusion Pediatric peptic ulcers were predominantly found in school-age and adolescent male children,with duodenal ulcer as the commonly-seen type,and abdominal pain,vomiting,and black stool as the main clinical features.Family history,cold food preference,hot and sour taste preference,frequent takeaways diet,Helico

关 键 词：儿童 消化性溃疡 十二指肠溃疡 复合性溃疡 胃溃疡 临床特征 危险因素 LOGISTIC回归分析 

分 类 号：R725.7[医药卫生—儿科]