沙库巴曲缬沙坦治疗老年慢性心功能不全的有效性及安全性  

Efficacy and safety of salkubatrol and valsartan in the treatment of elderly chronic cardiac insufficiency

作　　者：王芬 李芝 汪小丽 WANG Fen;LI Zhi;WANG Xiaoli(Department of General Practice,Shangrao Municipal Hospital,Shangrao,Jiangxi,334000,China)

机构地区：[1]上饶市立医院全科医疗科,江西上饶334000

出　　处：《当代医学》2023年第33期142-145,共4页Contemporary Medicine

摘　　要：目的探讨沙库巴曲缬沙坦治疗老年慢性心功能不全的有效性及安全性。方法选取2018年2月至2020年2月上饶市立医院收治的80例慢性心功能不全患者作为研究对象,按照治疗方式不同分为对照组(n=39)与观察组(n=41)。对照组给予常规治疗,观察组在对照组治疗基础上联合沙库巴曲缬沙坦治疗,比较两组临床疗效、1年生存率及超声心动图相关指标[左心室舒张末期内径(LVDD)、左心室射血分数(LVEF)及左心室短轴缩短率(FS)]。结果观察组治疗总有效率为95.12%,高于对照组的76.92%,差异有统计学意义(P<0.05)。治疗后,两组LVEF、FS均高于治疗前,LVDD短于治疗前,且观察组LVEF、FS均高于对照组,LVDD短于对照组,差异有统计学意义(P<0.05)。观察组1年生存率高于对照组,差异有统计学意义(P<0.05)。结论常规治疗联合沙库巴曲缬沙坦治疗慢性心功能疗效确切,可有效缓解患者症状,改善血流动力学变化,延长患者生存期,提高其生命质量,值得临床推广应用。Objective To explore the efficacy and safety of salkubatrol and valsartan in the treatment of elderly chronic cardiac insufficiency.Methods A total of 80 patients with chronic cardiac insufficiency admitted to Shangrao Municipal Hospital from February 2018 to February 2020 were selected as the research subjects,and they were divided into the control group(n=39)and the observation group(n=41)according to different treatment methods.The control group was given routine treatment,and the observation group was treated with salkubatrol and valsartan on the basis of the control group.The clinical efficacy,1-year survival rate and echocardiographic indexes(left ventricular end diastolic dimension[LVDD],left ventricular ejection fraction[LVEF]and fractional shortening[FS])were compared between the two groups.Results The total effective rate in the observation group was 95.12%,which was higher than 76.92%in the control group,the difference was statistically significant(P<0.05).After treatment,the LVEF and FS of the two groups were higher than those before treatment,LVDD was shorter than that before treatment,and LVEF and FS in the observation group were higher than those in the control group,LVDD was shorter than that in the control group,and the differences were statistically significant(P<0.05).The 1-year survival rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Conventional treatment combined with salkubatrol and valsartan is effective in the treatment of chronic cardiac function,it can effectively alleviate the symptoms of patients,improve hemodynamic changes,prolong the survival time of patients,and improve their quality of life,which is worthy of clinical promotion and application.

关 键 词：沙库巴曲缬沙坦 老年慢性心功能不全 超声心动图 

分 类 号：R541[医药卫生—心血管疾病]