预后营养指数评估原发性肝癌肝切除病人预后的Meta分析  

Prognostic evaluation of prognostic nutritional index for patients with hepatectomy for primary hepatocellular carcinoma:a Meta-analysis

作　　者：吴光柳 周小英[1] 杨雪梅[1] 尹如娇 WU Guangliu;ZHOU Xiaoying;YANG Xuemei;YIN Rujiao(The Second Affiliated Hospital of Kunming Medical University,Yunnan 650101 China)

机构地区：[1]昆明医科大学第二附属医院,云南650101

出　　处：《循证护理》2024年第3期392-395,共4页Chinese Evidence-Based Nursing

基　　金：中华护理学会科研课题,编号:ZHKYQ202105。

摘　　要：目的:系统评价预后营养指数(PNI)与原发性肝癌(HCC)肝切除病人预后的关系。方法:全面检索PubMed、百度学术、CINAHL、Google Scholar、Web of Science、OVID、中国生物医学文献数据库、中国知网、万方数据库和维普数据库中关于PNI和肝癌肝切除病人预后关系的文献,检索时限为建库至2022年5月31日,使用RevMan 5.2软件进行Meta分析。结果:共纳入6篇文献,涉及1 459例病人。Meta分析结果显示,低PNI与原发性肝癌肝切除病人的总生存期(OS)[HR=1.94,95%CI(1.53,2.44),P<0.001]、无复发生存期(RFS)[HR=1.59,95%CI(1.34,1.89),P<0.001]相关。亚组分析显示:中国人群[HR=1.95,95%CI(1.53,2.48)]与日本人群[HR=1.96,95%CI(1.21,3.18)]的PNI对肝癌肝切除病人的预测价值均有明显差异,同时PNI值为45.00~49.50对肝癌肝切除病人有较好的预测效果。结论:现有证据表明,PNI水平与肝癌肝切除病人OS、RFS明显相关,低PNI可作为此类病人预后预测的有效标志物。Objective:To systematically evaluate the relationship between prognostic nutritional index(PNI)and prognosis in patients with hepatectomy for primary hepatocellular carcinoma(HCC).Methods:A comprehensive retrieval of literature on the relationship between PNI and prognosis of patients with hepatectomy for HCC was conducted from PubMed,Baidu Scholar,CINAHL,Google Scholar,Web of Science,OVID,CBM,CNKI,WanFang Database and VIP.The retrieval time was from the inception to May 31,2022.Meta-analysis was performed using RevMan 5.2 software.Results:A total of 6 articles,including 1459 patients were included in the Meta-analysis.There was statistically significant difference in OS between patients with low PNI and those with high PNI(HR=1.94,95%CI 1.53-2.44,P<0.001),RFS of patients with low PNI was significantly different from those with high PNI(HR=1.59,95%CI 1.34-1.89,P<0.001),subgroup analysis showed:the predictive value of PNI in HCC patients with hepatectomy was significantly different between Chinese population(HR=1.95,95%CI 1.53-2.48)and Japanese population(HR=1.96,95%CI 1.21-3.18),and PNI between 45.00 and 49.50 had better predictive effect.Conclusion:Current evidence shows that PNI levels were significantly correlated with OS and RFS in HCC patients undergoing hepatectomy,and low PNI could be used as an effective prognostic marker for such patients.

关 键 词：原发性肝癌 预后营养指数 预后 META分析 循证护理 

分 类 号：R473.73[医药卫生—护理学]