口服氨甲环酸联合超分子水杨酸换肤治疗黄褐斑的疗效及对血清MDA与E_(2)的影响  

Observation of Curative Effect of Tranexamic Acid Combined with Supramolecular Salicylic Acid Peeling in the Treatment of Melasma and Its Influences on Serum MDA and E_(2)

作　　者：项倩彤 崔伟[1] 张慧[1] XIANG Qiantong;CUI Wei;ZHANG Hui(Department of Dermatology,the Second People's Hospital of Hefei(Hefei Hospital Affiliated to Anhui Medical University),Hefei 230011,Anhui,China)

机构地区：[1]合肥市第二人民医院(安徽医科大学附属合肥医院)皮肤科,安徽合肥230011

出　　处：《中国美容医学》2024年第1期95-98,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨氨甲环酸联合超分子水杨酸换肤治疗黄褐斑临床疗效及对血清丙二醛(MDA),雌二醇(E2)水平的影响。方法:将2019年12月-2021年12月合肥市第二人民医院皮肤科经治的116例黄褐斑患者随机分为对照组(58例,口服氨甲环酸片)和观察组(58例,口服氨甲环酸片联合30%超分子水杨酸治疗),两组患者均治疗20周。比较两组患者临床疗效[医生整体评价(Physician's global assessment,PGA)、黄褐斑面积和严重指数(Melasma area and severity index,MASI)、皮损评分、经表皮水分流失及皮肤角质层含水量]、主观指标(满意度、睡眠及精神状态)及血清MDA、E2水平。结果:观察组有效率93.10%高于对照组63.79%(P<0.05);两组治疗后MASI、皮损评分、经表皮水分流失及血清MDA、E2水平均较治疗前下降,且观察组改善优于对照组(P<0.05);两组治疗后角质层含水量均升高,且观察组升高更显著(P<0.05)。观察组PGA评分低于对照组(P<0.05)。观察组治疗后治疗满意度评分、睡眠评分、精神状态评分显著高于对照组(P<0.05)。两组治疗期间均未出现不良反应。结论:氨甲环酸联合超分子水杨酸换肤治疗黄褐斑效果显著,并可改善患者氧化应激反应及雌激素水平。Objective To investigate the therapeutic effect of tranexamic acid combined with supramolecular salicylic acid peeling on melasma and its influences on serum malondialdehyde(MDA)and estradiol(E2)levels.Methods From December 2019 to December 2021,116 patients with melasma who were admitted to the department of dermatology of hefei second people's hospital were randomly divided into the control group(58 cases,oral tranexamic acid tablets)and the observation group(58 cases,salicylic acid peeling treatment on the basis of the control group),20 weeks were treated every group.the clinical efficacy,skin lesions[including physician's global assessment(PGA),melasma area and severity index(MASI)skin lesion score,transepidermal water loss and stratum corneum water content],subjective indicators(including treatment satisfaction,sleep and mental states),adverse reactions and serum MDA and E2 levels were compared between the two groups.Results The effective rate of 93.10%in the observation group was higher than 63.79%in the control group(P<0.05);After treatment,MASI,skin lesion score,transepidermal water loss,and serum MDA and E2 levels decreased in both groups compared to before treatment,and the improvement in the observation group was better than that in the control group(P<0.05);The moisture content of the stratum corneum increased after treatment,and the observation group showed a more significant increase(P<0.05).The PGA score of the observation group was lower than that of the control group(P<0.05).The satisfaction score,sleep score,and mental state score of the observation group after treatment were significantly higher than those of the control group(P<0.05).No adverse reactions occurred during the treatment of both groups.Conclusion Tranexamic acid combined with supramolecular salicylic acid peeling has a significant therapeutic effect on melasma,and can improve the oxidative stress and estradiol level in patients.

关 键 词：黄褐斑 氨甲环酸 超分子水杨酸 换肤 丙二醛 雌二醇 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]