沉香叶的镇痛抗炎作用研究  

Study on the analgesic and anti-inflammatory activity of theleaves of Aquilaria sinensis

作　　者：王三炜 谢言青 金叶 周志宏 刘录 WANG San-wei;XIE Yan-qing;JIN Ye;ZHOU Zhi-hong;LIU Lu(Yunnan Yunzhong Institute of Nutrition and Health,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学云南云中营养与健康研究院,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2024年第1期17-22,共6页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：云南省高校工程研究中心(2020YGG01);云南省教育厅民族药物质基准研究重点实验室(2022YGZ02);云南省高层次人才专项项目(YNWR-QNBJ-2020-280).

摘　　要：研究沉香叶醇提物抗炎镇痛药理作用,并对作用机制进行初步研究.利用经典痛刺激(热板法、醋酸扭体)模型和小鼠耳廓肿胀抗炎模型来评价沉香叶醇提物的镇痛、抗炎效果,并通过检测血清、耳组织中的因子,推测其作用机制.沉香叶醇提物能明显减少小鼠的扭体次数、提高小鼠的痛阈值,且对二甲苯致小鼠耳廓肿胀有明显的抑制作用.沉香叶醇提物对小鼠具有镇痛作用,其作用机制可能与降低小鼠血清中的PGE 2、BK和提高β-EP的含量有关;沉香叶醇提物对小鼠具有抗炎作用,其作用机制可能与降低小鼠耳组织中的致炎因子TNF-α、IL-β和提高抗炎因子IL-4、IL-10的含量有关.The pharmacological effects of agarwood leaf alcohol extract on anti-inflammatory and analgesic effects were studied,and the mechanism of action was preliminarily studied.Study and mechanism anti-inflammatory and analgesic activity and mechanism of the leaves of Aquilaria sinensis.Using the classical pain stimulation(hot plate method,acetic acid twist)model and the mouse auricular swelling anti-inflammatory model,the alcoholic extract of the leaves of A.sinensis was evaluated in terms of their anti-inflammatory and analgesic effects.The ethanol extract of leaves of A.sinensis can significantly reduce the number of writhing in mice,increase the pain threshold of mice,and has a significant inhibitory effect on xylene induced auricle swelling in mice.The leaves of A.sinensis has anti-inflammatory effect and analgesic effect on mice,which may be related to the reduction of inflammatory factors TNF-αand IL-βand the increase of anti-inflammatory factors IL-4 and IL-10 in mouse ear tissue and may be related to the reduction of PGE 2 and BK in mice serum and the increase ofβ-EP content,respectively.

关 键 词：沉香叶 镇痛 抗炎 

分 类 号：R284[医药卫生—中药学]