药动学-药效学结合模型在中医药领域中的应用与展望  

Outlook and application of integrated pharmacokinetics-pharmacodynamics modelings in traditional Chinese medicine

作　　者：惠梦雨 刘平 张华[1,2,3] HUI Mengyu;LIU Ping;ZHANG Hua(Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China;Shanghai Key Laboratory of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203 [2]肝肾疾病病证教育部重点实验室,上海201203 [3]上海市中医临床重点实验室,上海201203 [4]上海中医药大学交叉科学研究院,上海201203

出　　处：《上海中医药杂志》2024年第2期40-45,共6页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81673849);上海市科委科研计划项目(19401972700)。

摘　　要：药动学-药效学(PK-PD)结合模型研究目的在于确定药物浓度与效应以及药物在体内的动态变化对药效强度及持续时间的影响。不同于化学药物有明确的成分与作用机制,中药具有多成分、多靶点、多途径、多效应的特点,因此PK-PD结合模型在中医药领域中的应用尚不成熟。基于中药PK-PD结合模型研究现状,建立多学科交叉的中医药PK-PD结合模型研究体系及探索建立合适的PK-PD结合模型分析中西药联合应用的量-时-效间关系,有望为中药研究及其合理应用、开发以及确定剂量、剂型等方面提供参考。The research aim of integrated pharmacokinetics-pharmacodynamics(PK-PD)modelings is to determine the effect of drug concentration and efficacy,as well as the dynamic changes of drugs in vivo on the intensity and duration of drug effects.Unlike chemical drugs with well-defined components and mechanisms of action,traditional Chinese herbal medicines(TCHMs)have multiple components,targets,pathways and effects,making the application of the integrated PK-PD modelings still immature in the field of TCM.Based on the research status quo of integrated PK-PD modelings in TCM,this paper establishes a multidisciplinary TCM integrated PK-PD modelings research system,and explores on the establishment of an appropriate integrated PK-PD modeling to analyze the dose-time-efficacy relationships in the case of combined use of Chinese and Western medicines.It is hoped that this review can provide references for TCHMs research,rational application and development,as well as dosage and dosage form determination.

关 键 词：中药 药动学 药效学 PK-PD结合模型 效应成分 量效关系 学科交叉 

分 类 号：R285[医药卫生—中药学]