慢性心力衰竭患者血清Hcy和NT-proBNP水平变化及其意义探讨  

Changes and significance of serum Hcy and NT-proBNP levels in patients with chronic heart failure

作　　者：胡仁学 HU Renxue(Department of Cardiology,Zhenjiang Dantu District People's Hospital,Zhenjiang Jiangsu 212000,China)

机构地区：[1]镇江市丹徒区人民医院心内科,江苏镇江212000

出　　处：《实用心电学杂志》2024年第1期59-61,66,共4页Journal of Practical Electrocardiology

摘　　要：目的研究慢性心力衰竭患者血清Hcy和NT-proBNP水平的变化及其意义。方法选取慢性心力衰竭患者102例纳入观察组,以及同期体检的102例健康体检者作为对照组。两组均进行血清Hcy、NT-proBNP的检测并比较检测结果,同时测定左心室射血分数(LVEF),分析血清Hcy、NT-proBNP水平与LVEF的相关性。结果观察组治疗前后的血清Hcy、NT-proBNP水平均高于对照组,LVEF均低于对照组,且差异有统计学意义(P<0.05)。观察组治疗前血清Hcy、NT-proBNP水平随着NYHA分级的增高而升高,LVEF则随之下降;不同分级患者上述指标比较,差异均有统计学意义(P<0.05),且血清Hcy、NT-proBNP水平与LVEF呈负相关(P<0.05)。结论血清Hcy、NT-proBNP水平的变化能够较好地反映慢性心力衰竭患者的心功能分级和病情严重程度。Objective To study the changes and significance of serum Hcy and NT-proBNP levels in patients with chronic heart failure.Methods We selected 102 patients with chronic heart failure as the observation group while another 102 healthy physical examinees during the same period were enrolled as the control group.The serum Hcy and NT-proBNP levels were separately tested in the two groups,and made comparison.Meanwhile,left ventricular ejection fraction(LVEF)was measured.The correlation between serum Hcy,NT-proBNP and LVEF was analyzed.Results The serum Hcy and NT-proBNP levels of the observation group before and after treatment were higher than those of the control group while LVEF was lower than that of the control group with statistically significant differences(P<0.05).Before treatment,the levels of serum Hcy and NT-proBNP in the observation group increased with the upgraded NYHA grading while LVEF decreased;there was a statistically significant difference of each index among the patients with different NYHA grades in pairwise comparison(P<0.05).The levels of serum Hcy and NT-proBNP were negatively correlated with LVEF(P<0.05)before treatment.Conclusion The changes of serum Hcy and NT-proBNP levels could reflect the cardiac function grading and severity of patients with chronic heart failure.

关 键 词：慢性心力衰竭 同型半胱氨酸 N末端脑利钠肽前体 NYHA分级 

分 类 号：R541.9[医药卫生—心血管疾病]