冠心宁联合氨氯地平治疗高血压合并心力衰竭的疗效及其对血清miR-196a-2、sFas的影响  

Effect of Guanxinning combined with amlodipine on hypertension complicating heart failure and its influence on serum miR-196a-2 and sFas

作　　者：张婵 ZHANG Chan(Department of Cardiology,Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu Henan 476400,China)

机构地区：[1]商丘市中医院心病科,河南商丘476400

出　　处：《实用心电学杂志》2024年第1期62-66,共5页Journal of Practical Electrocardiology

摘　　要：目的探讨冠心宁联合氨氯地平治疗高血压合并心力衰竭(简称心衰)的疗效及其可能的作用机制。方法选取83例高血压合并心衰患者作为研究对象,采用随机数字表法分为对照组41例(氨氯地平治疗)、观察组42例(冠心宁联合氨氯地平治疗)。比较两组临床疗效及治疗前后心功能指标(LVEF、LVESd、LVEDd、IVST、NT-proBNP)、血压、血凝指标、血管内皮功能指标[内皮素-1、一氧化氮(NO)、血管紧张素Ⅱ(AngⅡ)]、血清学指标[微小RNA-196a-2(microRNA-196a-2,miR-196a-2)、可溶性凋亡调节因子(soluble factor associated suicide,sFas)]水平的变化。结果观察组总有效率高于对照组(P<0.05);观察组治疗后LVEF、IVST高于对照组,LVESd、LVEDd、收缩压、舒张压、低切全血黏度、血浆黏度、红细胞聚集指数低于对照组(P<0.05);观察组治疗后血清NT-proBNP、内皮素-1、AngⅡ、miR-196a-2、sFas水平低于对照组,NO水平高于对照组(P<0.05)。结论冠心宁联合氨氯地平治疗高血压合并心衰疗效确切,可促进心功能恢复,改善血压、凝血功能、血管内皮功能,其作用机制可能与调节miR-196a-2和sFas的表达有关。Objective To investigate the efficacy and possible mechanism of Guanxining combined with amlodipine in the treatment of hypertension complicating heart failure(HF).Methods Eighty-three patients with hypertension complicating HF were selected as the study subjects.They were divided into control group(41 cases,treated by amlodipine)and observation group(42 cases,treated by Guanxinning combined with amlodipine)by random number table method.We compared the clinical efficacy between the two groups as well as changes of cardiac function(LVEF,LVESd,LVEDd,IVST and NT-proBNP),blood pressure,blood coagulation indexes,vascular endothelial function[endothelin-1,NO,angiotensinⅡ(AngⅡ)],and serological indexes[microRNA-196a-2(miR-196a-2)and soluble factor associated suicide(sFas)]levels before and after the treatment.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,LVEF and IVST in the observation group were higher than those in the control group while LVESd,LVEDd,systolic blood pressure,diastolic blood pressure,low-shear whole blood viscosity,plasma viscosity and red blood cell aggregation index were lower than those in the control group(P<0.05).After treatment,the levels of serum NT-proBNP,endothelin-1,AngⅡ,miR-196a-2 and sFas in the observation group were lower than those in the control group while the level of NO was higher than that in the control group(P<0.05).Conclusion Guanxinning combined with amlodipine is effective in the treatment of hypertension complicated with HF.It could promote the recovery of cardiac function,and improve blood pressure,coagulation function and vascular endothelial function.Its mechanism may be related to the regulation of expression of miR-196a-2 and sFas.

关 键 词：高血压 心力衰竭 冠心宁 氨氯地平 疗效 

分 类 号：R544.2[医药卫生—心血管疾病] R541.9[医药卫生—内科学]