基于皮层-基底神经节环路模型的经颅磁声电刺激对大鼠行为决策的影响  

Effect of Transcranial Magneto-Acousto-Electrical Stimulation on Behavioral Decision-Making in Rats Based on a Cortical-Basal Ganglia Loop Model

作　　者：张帅[1,2,3] 由胜男 党君武 杜文静 王磊[1,2,3] Zhang Shuai;You Shengnan;Dang Junwu;Du Wenjing;Wang Lei(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130 China;Hebei key Laboratory of Bioelectromagnetism and Neural Engineering,Hebei University of Technology,Tianjin 300130 China;Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health,Hebei University of Technology,Tianjin 300130 China)

机构地区：[1]省部共建电工装备可靠性与智能化国家重点实验室河北工业大学,天津300130 [2]河北工业大学河北省生物电磁与神经工程重点实验室(筹),天津300130 [3]天津市生物电工与智能健康重点实验室河北工业大学,天津300130

出　　处：《电工技术学报》2024年第2期356-368,共13页Transactions of China Electrotechnical Society

基　　金：国家自然科学基金(51877069、52107236);河北省科技计划等(E2021202184、236Z7711G、QN2021043)资助项目。

摘　　要：经颅磁声电刺激(TMAES)是一种新型、无创、可改变不同脑区电活动的神经调控方法。前额叶皮层与基底神经节中各脑区相互影响,在行为决策中起着关键作用,然而目前涉及其调节机理的研究相对较少。前运动皮层神经元活性和前额叶皮层突触可塑性与行为决策关系密切。该文基于皮层-基底神经节回路模型,模拟分别对健康大鼠、帕金森大鼠施加刺激后,不同脑区在奖赏选择任务中的神经活动,仿真分析不同感应电流强度对皮层神经元放电率和脑区间突触权重的影响。并通过行为学实验进一步探讨经颅磁声电刺激对健康大鼠与帕金森模型大鼠行为决策的影响。仿真结果显示,对健康大鼠施加刺激可提高前额叶皮层与纹状体、前运动皮层之间的突触权重;对帕金森大鼠施加刺激可提高前运动皮层神经元放电率,调节前额叶皮层与纹状体、前运动皮层之间的突触权重。实验结果显示,施加刺激后,大鼠的学习探索能力和空间记忆能力均得到了提高,且帕金森模型大鼠受刺激的作用效果更显著。研究结果表明,经颅磁声电刺激可提高大鼠的运动积极性和学习效率,且有助于改善基底神经节的功能失衡。研究结果为进一步探索经颅磁声电刺激调节决策认知功能的作用机制奠定基础。Transcranial magneto-acousto-electrical stimulation(TMAES)is a novel noninvasive neuromodulation technique that can modulate electrical activity in different brain regions.Brain regions in the cortex and basal ganglia interact with each other and play a key role in behavioral selection and reinforcement learning.Based on the cortical-basal ganglia circuit model,this study explored the effect of TMAES on the behavioral decision-making ability of rats and further discussed the effect of stimulation on neural information transmission and spatial exploration ability of rats through animal experiments.TMAES uses the coupling effect of magnetic field and ultrasound to generate induced current in nerve tissue,which affects the neural activity of the cortex-basal ganglia circuit.The discharge rate of premotor cortex(PMC)neurons is related to exercise enthusiasm.The synaptic connection between the prefrontal cortex(PFC)and striatum(STR)is involved in evaluating brain action value.The synaptic connection between PFC and PMC is closely related to learning and memory.This paper aims to investigate the regulatory mechanism of TMAES on the cortical-basal ganglia-cortical neural network in healthy and Parkinsonian states.Based on the cortical-basal ganglia-cortical circuit model,this paper simulated the neural activity of different brain regions in a reward selection task.The effects of different induced current strengths on the firing rate of neurons and the synaptic weight between nuclei were also analyzed.The simulation results showed that when TMAES was applied to healthy rats,the discharge rate of PMC nuclei corresponding to rewarding and non-rewarding behaviors increased and decreased,respectively.When the induced current was 100μA/cm2,the number of rewarding behaviors in 1~200 trials increased from 177 to 195 and increased from 167 to 187 in 200~400 trials.At the same time,stimulation increased the synaptic weight and was positively correlated with the induced current.The discharge rate of the PMC nucleus and the promin

关 键 词：经颅磁声电刺激 皮层神经元 基底神经节 行为决策 突触权重 

分 类 号：TM12[电气工程—电工理论与新技术] R318[医药卫生—生物医学工程]