基于数据挖掘中药治疗高原性缺氧的组方规律  

Medication rule of traditional Chinese medicine in the treatment of plateau hypoxia based on data mining

作　　者：王仁杰 罗凯 杨军 钱庆元 李晓琳 高月 李茂星 WANG Renjie;LUO Kai;YANG Jun;QIAN Qingyuan;LI Xiaolin;GAO Yue;LI Maoxing(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730020;Institute of Radiation Medicine Sciences,Academy of Military Medicine,Academy of Military Sciences,Beijing 100850;School of Pharmacy,Lanzhou University,Lanzhou 730020;Department of Pharmacy,940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学药学院,兰州730020 [2]军事科学院军事医学研究院辐射医学研究所,北京100850 [3]兰州大学药学院,兰州730020 [4]联勤保障部队第九四〇医院药剂科,兰州730050

出　　处：《中南大学学报（医学版）》2023年第10期1453-1463,共11页Journal of Central South University ：Medical Science

基　　金：国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-D-202207)。

摘　　要：目的:中医药在高原地区的发展相对滞后,高原低压、低氧的特殊环境对人体经脉气血的影响,以及高原性缺氧导致的疾病的病因、病机分析缺乏体系。运用数据挖掘方法,分析、挖掘中药抗高原性缺氧组方规律,为抗高原性缺氧的中医药组方提供参考和借鉴。方法:检索中国知网、万方医学网、维普网、中国生物医学文献等数据库中与高原性缺氧相关的实验性文献,对文献中处方数据进行筛选、标准化等处理后建立标准化处方数据库,分析抗高原性缺氧处方中用药频次、药物属性、药物功效、药物组合、核心处方等组方规律,并利用图表进行可视化展示。结果:共纳入135首中药处方,包括229味药物。其中使用频次较高的中药为黄芪、丹参、人参、当归等;中药四气多为温、平之性;中药五味多为甘、苦、辛味;中药归经多入心、肺、肝经;中药功效统计中生津养血频次最高;中药配伍中黄芪-丹参、黄芪-当归关联频次较高。其核心用药为黄芪、丹参、当归、红景天、枸杞子、人参等。中药能够缓解高原性缺氧引起的胸闷、胸痛、咳喘、咳嗽、呕吐、乏力、食欲减退等症状。结论:本研究通过数据挖掘,分析得出防治高原性缺氧相关疾病多用生津养血、补气化瘀、助阳化气之品,多以补气药和活血化瘀药相配伍,并且注重虚实结合,阴阳并补。Objective:The development of traditional Chinese medicine(TCM)in the plateau area is relatively backward.There is a lack of system to analyze the effects of the special environment of plateau low pressure and hypoxia on human meridians qi and blood,as well as the etiology and pathogenesis of plateau hypoxic diseases.To analyze the composition rules of anti-hypoxia TCM formulation with data mining methods.Methods:The experimental literatures related to high altitude hypoxia were searched in China National Knowledge Infrastructure(CNKI),Wanfang Med Online,VIP,China Biology Medicine disc and other databases,a standardized prescription database was established after screening and standardization of prescription data in the literature.The composition rules of these prescription including drug frequency,drug attributes,drug efficacy,drug combination,and core prescription were analyzed and displayed with visual charts.Results:A total of 135 TCM prescriptions were included,and 229 flavored drugs were included.Among these prescriptions,the TCM with high frequency of use were Astragalus,Danshen,Ginseng,and Angelica,etc.Four natures of the TCM were mostly warm and calm.Five flavours of the TCM were mostly sweet,bitter,and pungent.And channel tropism of the TCM mostly entered the heart,lung,and liver meridians.The frequency combination of TCM was Astragalus-Danshen and Astragalus-Angelica.The core medicines of these prescriptions were Astragalus,Danshen,Angelica,Rhodiola,Goji,and Ginseng.TCM could alleviate symptoms such as chest tightness,chest pain,coughing and wheezing,coughing,vomiting,fatigue,and loss of appetite caused by hypoxia at high altitude.Conclusion:Through data mining,it is concluded that the prevention or treatment of plateau hypoxic diseases mostly utilized products can nourish blood,replenish qi and dispel stasis,and help yang and dispel qi,most of them are compatible with qi tonic drugs and blood circulation and stasis dissolving drugs,and pay attention to the combination of virtual and real,yin and yang.

关 键 词：高原性缺氧 中药 数据挖掘 组方规律 

分 类 号：R259[医药卫生—中西医结合]