血栓闭塞性脉管炎与同型半胱氨酸及纤维蛋白原的关系  

Relationship between thromboangiitis obliterans and homocysteine and fibrinogen

作　　者：高红霞 郝斌[1,2] 杨涛 续慧民 孙磊[1,2] Gao Hongxia;Hao Bin;Yang Tao;Xu Huimin;Sun Lei(Department of Vascular Surgery,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji ShanxiHospital,Third Hospital of Shanxi Medical University,Taiyuan 030032,Shanxi,China;Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei,China)

机构地区：[1]山西白求恩医院(山西医学科学院同济山西医院),山西医科大学第三医院血管外科,山西太原030032 [2]华中科技大学同济医学院附属同济医院,湖北武汉430030

出　　处：《血管与腔内血管外科杂志》2023年第12期1440-1443,共4页Journal of Vascular and Endovascular Surgery

基　　金：“136兴医工程建设经费”基金资助。

摘　　要：目的探讨血栓闭塞性脉管炎(TAO)与同型半胱氨酸(Hcy)、纤维蛋白原(FIB)水平的关系。方法收集2014年1月至2022年12月因TAO于山西白求恩医院(山西医学科学院同济山西医院),山西医科大学第三医院接受治疗的56例TAO患者的临床资料,设为TAO组(n=56)。选取同期进行体检的健康者设为对照组(n=56)。比较两组受试者的Hcy和FIB水平,并采用Logistic回归模型和Spearman法进一步明确Hcy、FIB水平与TAO发生的关系。结果TAO组受试者的Hcy、FIB水平均明显高于对照组受试者,差异有统计学意义(P﹤0.01)。多因素分析结果显示,Hcy、FIB水平均是TAO发生的影响因素(P﹤0.05)。通过绘制散点图可见Hcy与FIB水平之间无明确的相关性。Spearman相关性分析结果显示,Hcy与FIB水平之间无相关性(r=1.000,P=0.089)。结论与健康体检者相比,TAO患者的Hcy、FIB水平明显升高,Hcy、FIB水平均是TAO发生的独立危险因素,给予降低Hcy、FIB水平的治疗可能对于TAO的治疗有益。Objective To investigate the relationship between thromboangiitis obliterans(TAO)and levels of homocysteine(Hcy)and fibrinogen(FIB).Method The clinical data of 56 TAO patients who received treatment for TAO from January 2014 to December 2022 at Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Third Hospital of Shanxi Medical University,and set them as the TAO group(n=56).Healthy individuals who underwent physical examinations during the same period were selected as the control group(n=56).The Hcy and FIB levels of subjects in two groups were compared,and the relationship between Hcy,FIB levels and TAO occurrence was further clarified using Logistic regression model and Spearman method.Result The Hcy and FIB levels of TAO group subjects were significantly higher than those of the control group subjects,and the differences were statistically significant(P<0.01).The results of multivariate analysis showed that Hcy and FIB levels were both influencing factors for the occurrence of TAO(P<0.05).By drawing a scatter plot,it can be 1441 Journal of Vascular and Endovascular Surgery Vol.9,No.12,Dec 2023 seen that there is no clear correlation between Hcy and FIB levels.The Spearman correlation analysis showed no correlation between Hcy and FIB levels(r=1.000,P=0.089).Conclusion The levels of Hcy and FIB in patients with TAO are significantly higher than those in healthy individuals who underwent physical examinations,and they are independent risk factors for TAO.The methods of lowering the levels of Hcy and FIB may be beneficial to the treatment of TAO.

关 键 词：血栓闭塞性脉管炎 同型半胱氨酸 纤维蛋白原 影响因素 相关性 

分 类 号：R543[医药卫生—心血管疾病]