经皮人工血栓抽吸联合利伐沙班对深静脉血栓患者凝血酶调节蛋白、P-选择素的影响  

Effect of percutaneous artificial thrombus aspiration combined with rivaroxaban on thrombomodulin and P-selectin in patients with deep vein thrombosis

作　　者：张永辉 李云霞 郑晓拓 Zhang Yonghui;Li Yunxia;Zheng Xiaotuo(Department of Vascular Surgery,the Fourth Central Hospital of Baoding City,Baoding 072350,Hebei,China;Department of Laboratory,the Fourth Central Hospital of Baoding City,Baoding 072350,Hebei,China)

机构地区：[1]保定市第四中心医院血管外科,河北保定072350 [2]保定市第四中心医院检验科,河北保定072350

出　　处：《血管与腔内血管外科杂志》2023年第12期1460-1464,共5页Journal of Vascular and Endovascular Surgery

基　　金：河北省医学科学研究课题(20211488)。

摘　　要：目的探讨经皮人工血栓抽吸联合利伐沙班对深静脉血栓(DVT)患者的治疗效果及对凝血酶调节蛋白(TM)、P-选择素(P-selectin)的影响。方法选取2019年6月至2021年6月保定市第四中心医院收治的110例DVT患者,按随机数字表法分为观察组和对照组,每组55例。比较两组患者的临床疗效、凝血功能指标[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]、血小板参数[血小板计数(PLT)、血小板分布宽度(PDW)、平均血小板体积(MPV)]水平、血清学指标[凝血酶调节蛋白(TM)、P-选择素、血栓前体蛋白(TpP)]水平及不良反应发生情况。结果观察组患者的总有效率高于对照组患者,差异有统计学意义(P﹤0.05)。治疗后,两组患者的PT、TT、APTT均长于本组治疗前,FIB水平低于本组治疗前,且观察组患者的PT、TT、APTT均长于对照组患者,FIB水平低于对照组患者,差异均有统计学意义(P﹤0.05)。治疗后,两组患者的PLT、PDW、MPV水平均低于本组治疗前,且观察组患者的上述指标水平均低于对照组患者,差异均有统计学意义(P﹤0.05)。治疗后,两组患者的TM、P-选择素、TpP水平均低于本组治疗前,且观察组患者的上述指标水平均低于对照组患者,差异均有统计学意义(P﹤0.05)。治疗期间,两组患者的不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论经皮人工血栓抽吸联合利伐沙班对DVT患者的溶栓效果显著,能够改善患者的凝血功能和血小板参数水平,降低血清学指标水平,安全性较高,可临床推广。Objective To investigate the therapeutic effect of percutaneous artificial thrombus aspiration combined with rivaroxaban on patients with deep vein thrombosis(DVT)and the effect of thrombomodulin(TM)and P-selectin.Method A total of 110 DVT patients admitted to the Fourth Central Hospital of Baoding City from June 2019 to June 2021 were selected.The patients were divided into observation group and control group according to the random number table method,with 55 cases in each group.The clinical efficacy,coagulation function indicators[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]levels,and platelet parameters[platelets count(PLT),platelet distribution width(PDW),mean platelet volume(MPV)],serological indexes[thrombomodulin(TM),P-selectin,thrombus precursor protein(TpP)]levels,and occurrence of adverse reactions were compared between the two groups of patients.Result The total effective rate of the patients in the observation group was higher than that of the patients in the control group,and the difference was statistically significant(P<0.05).After the treatment,the PT,TT,and APTT of the two groups of patients were all longer than those before the treatment,and the FIB level was lower than that before the treatment.The PT,TT,and APTT of the observation group were all longer than those of the control group,and the FIB level was lower than that of the control group,and the differences were all statistically significant(P<0.05).After the treatment,the PLT,PDW,and MPV levels of the two groups of patients were lower than those before treatment,and the foregoing index levels of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TM,P-selectin,and TpP in the two groups of patients were all lower than before the treatment,and the levels of the above indicators in the observation group were lower than those in the control group,and the differences were statisticall

关 键 词：下肢深静脉血栓 经皮人工血栓抽吸 利伐沙班 凝血功能 血小板参数 凝血酶调节蛋白 P-选择素 

分 类 号：R543[医药卫生—心血管疾病]