A型肉毒素联合5-氟尿嘧啶治疗成人瘢痕疙瘩的应用分析  

Application analysis of botox type A combined with 5-fluorouracil in the treatment of adult keloid

作　　者：周芮 居兴刚[2] 普潇 姜福星 Zhou Rui;Ju Xing-gang;Pu Xiao;Jiang Fu-xing(Department of Aesthetic Surgery,Doctor Mao Medical Aesthetic Plastic Surgery Hospital,Luoyang 471000,Henan,China;Department of Dermatology,The Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Xigong Doctor Mao Medical Cosmetology Clinic,Luoyang 471000,China)

机构地区：[1]毛大夫医疗美容整形医院美容外科,河南洛阳471000 [2]河南科技大学第二附属医院皮肤科,河南洛阳471000 [3]西工毛大夫医疗美容门诊部,河南洛阳471000

出　　处：《四川生理科学杂志》2024年第1期93-95,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨A型肉毒素(Botulinum Toxin A,BTX-A)与5-氟尿嘧啶(5-Fluorouracil,5-FU)联合治疗成人瘢痕疙瘩的疗效及安全性。方法:选取我院2018年3月至2022年9月期间收治的瘢痕疙瘩患者72例,按照随机数字法将患者分为研究组及对照组,每组各36例。对照组给予局部注射5-FU及复发倍他米松注射液治疗;研究组给予局部注射BTX-A及5-FU治疗。治疗16 w后采用瘢痕疙瘩体积缩小程度,采用视觉模拟评分(Visual Analogue Scale,VAS)分析对比两组的总有效率及痛痒程度,随访6 m对比两组复发率以及不良反应。结果:两组治疗后瘢痕疙瘩体积较治疗前均缩小,研究组及对照组总有效率分别为97.22%和91.67%,组间无差异(P>0.05)。两组治疗后VAS评分较治疗前均降低,研究组治疗后VAS评分较对照组更低(P<0.05)。随访6 m研究组及对照组复发率分别为2.78%和8.33%,组间无差异(P>0.05)。研究组不良反应发生率显著低于对照组(P<0.05)。结论:A型肉毒素联合5-氟尿嘧啶可有效治疗成人外伤后瘢痕疙瘩,且复发率及不良反应发生率较低。Objective:To investigate the efficacy and safety of Botulinum Toxin A(BTX-A)combined with 5-Fluorouracil(5-FU)in the treatment of adult keloids.Methods:A total of 72 patients with keloid treated in our hospital from March 2018 to September 2022 were selected and divided into study group and control group according to random number method,with 36 cases in each group.The control group was given local injection of 5-FU and relapsed betamethasone injection.The study group was treated with local injection of BTX-A and 5-FU.After 16 w of treatment,the reduction of keloid volume was analyzed and the total effective rate and itching degree of the two groups were compared by Visual Analogue Scale(VAS).After 6 months of follow-up,the recurrence rate and adverse reactions of the two groups were compared.Results:The volume of keloid was reduced in both groups after treatment.The total effective rate of study group and control group was 97.22% and 91.67%,respectively,with no difference between groups(P>0.05).VAS score after treatment was lower in both groups than before treatment,and VAS score after treatment in study group was lower than that in control group(P<0.05).The recurrence rates of the study group and the control group were 2.78% and 8.33%,respectively,after 6 months of followup(P>0.05).The incidence of adverse reactions in study group was significantly lower than that in control group(P<0.05).Conclusion:Botox A combined with 5-fluorouracil can effectively treat adult post-traumatic keloid,and the recurrence rate and the incidence of adverse reactions are low.

关 键 词：A型肉毒素 5-氟尿嘧啶 瘢痕疙瘩 疗效 安全性 

分 类 号：R75[医药卫生—皮肤病学与性病学]