血清CCL18、TIMP-1、Apelin表达与膝骨关节炎严重程度的相关性  

Correlation between the expression of CCL18,TIMP-1,and Apelin in serum and the severity of knee osteoarthritis

作　　者：闫理想 Yan Li-xiang(The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《四川生理科学杂志》2024年第1期96-99,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨血清CC趋化因子配体18(CC-chemokine ligand 18,CCL18)、基质金属蛋白酶抑制因子-1(Tissue inhibitor of metalloproteinase-1,TIMP-1)、APJ内源性配体(Apelin)表达与膝骨关节炎严重程度的相关性。方法:选取2021年10月至2022年10月我院接收的膝骨关节炎患者74例和体检健康人员100例,采用酶联免疫吸附法测定血清CCL18、TIMP-1、Apelin水平,采用Kellgren Lawrence(KL)分级评估膝骨关节炎严重程度,分析血清CCL18、TIMP-1、Apelin与膝骨关节炎严重程度的相关性。结果:与对照组相比,研究组KL-2级、KL-3级、KL-4级患者CCL18、Apelin水平升高,TIMP-1水平降低(P<0.05),且CCL18、Apelin、TIMP-1与WOMAC评分存在线性关联。CCL18、TIMP-1、Apelin是影响膝骨关节炎患者病情程度的危险因素(P<0.05)。结论:膝骨关节炎K-L分级与血清CCL18、TIMP-1、Apelin表达状态相关,可作为临床膝骨关节炎早期诊断及评估疾病进展的重要指标。Objective:To explore the relationship between serum CC-chemokine ligand 18(CCL18),tissue inhibitor of metalloproteinase-1(TIMP-1),APJ endogenous ligand(Apelin)expression,and correlation of knee osteoarthritis severity.Methods:A total of 74 cases of patients with knee osteoarthritis and 100 cases of health personnel admitted to our hospital from October 2021 to October 2022 were selected.Serum levels of CCL18,TIMP-1,and Apelin were measured by ELISA,and the severity of knee osteoarthritis was evaluated by Kellgren Lawrence(KL)scale.The correlation between serum CCL18,TIMP-1,Apelin,and the severity of knee osteoarthritis was analyzed.Results:Compared with the control group,the level of CCL18 and Apelin in KL-2,KL-3,and KL-4 patients in the study group was increased,while the level of TIMP-1 was decreased(P<0.05),and there was a linear correlation between CCL18,Apelin and TIMP-1 and WOMAC score.CCL18,TIMP-1,and Apelin were risk factors affecting the severity of knee osteoarthritis(P<0.05).Conclusion:The K-L grade of knee osteoarthritis is correlated with the expression of CCL18,TIMP-1,and Apelin in serum,which can be used as an important index for the early diagnosis and evaluation of the disease progression.

关 键 词：CC趋化因子配体18 基质金属蛋白酶抑制因子-1 APJ内源性配体 膝骨关节炎 严重程度 

分 类 号：R684.3[医药卫生—骨科学]