活性-非活性细胞界面动力学模型  

The Dynamic Model of the Active-Inactive Cell Interface

作　　者：张德清 张豪舜 李博[1] ZHANG Deqing;ZHANG Haoshun;LI Bo(Institute of Biomechanics and Medical Engineering,Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China)

机构地区：[1]清华大学工程力学系生物力学与医学工程研究所,北京100084

出　　处：《四川大学学报（医学版）》2024年第1期39-46,共8页Journal of Sichuan University(Medical Sciences)

基　　金：国家自然科学基金(No.12272202)资助。

摘　　要：目的利用活性液晶理论模型探究活性-非活性细胞界面的形貌动力学。方法采用活性液晶理论建立连续介质力学模型;通过对细胞单层的活性设置建立活性-非活性界面;通过有限差分及格子玻尔兹曼方法对理论方程进行数值求解分析。结果活性-非活性细胞单层界面呈现3种典型界面形貌,分别为直界面、波浪界面和指形界面。对于直界面,细胞取向在界面处垂直界面分布,−1/2拓扑缺陷聚集在界面,界面带负电属性;对于波浪界面,细胞取向在界面处无明显偏好,界面拓扑电荷数呈电中性;对于指形界面,细胞取向在界面处呈切向排列,+1/2拓扑缺陷聚集界面,驱动指形结构生长,界面带正电属性。结论界面处细胞排列取向会显著影响活性-非活性细胞界面形貌,这与界面的拓扑缺陷动力学密切相关。Objective To explore the morphodynamics of the active-inactive cell monolayer interfaces by using the active liquid crystal model.Methods A continuum mechanical model was established based on the active liquid crystal theory and the active-inactive cell monolayer interfaces were established by setting the activity difference of cell monolayers.The theoretical equations were solved numerically by the finite difference and the lattice Boltzmann method.Results The active-inactive cell interfaces displayed three typical morphologies,namely,flat interface,wavy interface,and finger-like interface.On the flat interfaces,the cells were oriented perpendicular to the interface,the−1/2 topological defects were clustered in the interfaces,and the interfaces were negatively charged.On the wavy interfaces,cells showed no obvious preference for orientation at the interfaces and the interfaces were neutrally charged.On the finger-like interfaces,cells were tangentially oriented at the interfaces,the+1/2 topological defects were collected at the interfaces,driving the growth of the finger-like structures,and the interfaces were positively charged.Conclusion The orientation of the cell alignment at the interface can significantly affect the morphologies of the active-inactive cell monolayer interfaces,which is closely associated with the dynamics of topological defects at the interfaces.

关 键 词：活性 细胞界面 拓扑缺陷 

分 类 号：Q27[生物学—细胞生物学]