苯扎氯铵阴道冲洗联合克霉唑治疗外阴阴道假丝酵母菌病的观察  

Observation of Benzalkonium Chloride Vaginal Irrigation Combined With Clotrimazole in the Treatment of Vulvovaginal Candidiasis

作　　者：李燕婷[1] 魏翠英[1] 杜丽萍 LI Yanting;WEI Cuiying;DU Liping(Department of Gynaecology and Obstetrics,the Second Affiliated Hospital of Fujian Medical University,Quanzhou Fujian 362000,China)

机构地区：[1]福建医科大学附属第二医院妇产科,福建泉州362000

出　　处：《中国卫生标准管理》2024年第1期160-163,共4页China Health Standard Management

摘　　要：目的探讨苯扎氯铵阴道冲洗联合克霉唑阴道栓对外阴阴道假丝酵母菌病的疗效及生活质量的影响。方法选取2020年1月—2023年3月福建医科大学附属第二医院外阴阴道假丝酵母菌病患者125例作为研究对象,采用随机数字表法分为对照组(62例)与观察组(63例)。对照组给予克霉唑阴道栓阴道栓塞治疗,观察组患者在克霉唑阴道栓的基础上,给予0.01%苯扎氯铵阴道冲洗。比较2组的疗效、欧洲五维健康量表(EuroQol Five Dimensions Questionnaire,EQ-5D)评分、治疗满意度及不良反应发生率。结果观察组有效率为80.95%(51/63),对照组为62.90%(39/62),差异有统计学意义(χ^(2)=6.763,P=0.034)。观察组疼痛/不舒服、焦虑/抑郁、总体状态等方面的生活质量评分均高于对照组,差异有统计学意义(P<0.05);而行动能力、自己照顾自己、日常活动评分与对照组比较,差异无统计学意义(P>0.05)。观察组总满意度为87.30%(55/63),对照组为77.42%(48/62),差异有统计学意义(χ^(2)=6.822,P=0.033)。结论苯扎氯铵阴道冲洗联合克霉唑阴道栓可以提高外阴阴道假丝酵母菌病的疗效,改善生活质量,提高护理满意度,安全性高。Objective To investigate the effect of vaginal flushing with benzalkonium chloride combined with clotrimazole vaginal suppository on the treatment and the quality of life of fungal vaginitis.Methods A total of 125 cases of fungal vaginitis in the Second Affiliated Hospital of Fujian Medical University from January 2020 to March 2023 were selected as the research objects,and were randomly divided into the control group(62 cases)and the observation group(63 cases).The patients in the control group were given clotrimazole vaginal suppository for vaginal embolization,and the patients in the observation group were given 0.01%benzalkonium chloride vaginal irrigation on the basis of clotrimazole vaginal suppository.The differences in efficacy,EuroQol five dimensions questionnaire(EQ-5D score),treatment satisfaction and incidence of adverse reactions between the two groups were compared.Results The effective rate of the observation group was 80.95%(51/63),while the control group was 62.90%(39/62),the differences were statistically significant(χ^(2)=6.763,P=0.034).The quality-of-life scores of pain/discomforts,anxiety/depression,and overall state in the observation group were higher than those in the control group,with statistical significance(P<0.05).The scores of action ability,self-care,and daily activities were similar to the control group,and the difference was not statistically significant(P>0.05).The total satisfaction rate of the observation group was 87.30%(55/63),while the control group was 77.42%(48/62),the differences were statistically significant(χ^(2)=6.822,P=0.033).Conclusion Vaginal flushing with benzalkonium chloride with clotrimazole vaginal suppository can improve the efficacy of fungal vaginitis,improve the quality of life,improve nursing satisfaction with high safety.

关 键 词：外阴阴道假丝酵母菌病 苯扎氯铵 阴道冲洗 克霉唑 生活质量 随机对照试验 

分 类 号：R711[医药卫生—妇产科学]