彩色多普勒超声联合miR-151a-3p、miR-1285-3p对结核性胸膜炎患者的诊断价值  

Diagnostic Value of Color Doppler Ultrasound Combined with miR-151a-3p and miR-1285-3p in Patients with Tuberculous Pleurisy

作　　者：高源 GAO Yuan(Ultrasound Department,Henan Chest Hospital/Chest Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]河南省胸科医院/郑州大学附属胸科医院超声科,河南郑州450000

出　　处：《河南医学研究》2024年第1期77-80,共4页Henan Medical Research

摘　　要：目的研究彩色多普勒超声联合miR-151a-3p、miR-1285-3p对结核性胸膜炎患者的诊断价值。方法选取2022年3月至2023年3月于河南省胸科医院就诊的100例结核性胸膜炎患者,记为TP组,选取健康对照组100例,记为CO组。对两组分别进行彩色多普勒超声及miR-151a-3p、miR-1285-3p检测,评估并分析两组检测结果。结果与CO组相比,TP组PSV升高,RI降低(P<0.05);与CO组相比,TP组血清miR-151a-3p表达升高,miR-1285-3p表达降低(P<0.05);PSV与血清中miR-151a-3p呈正相关(r=0.937,P<0.001)、与miR-1285-3p呈负相关(r=-0.835,P<0.001),RI与血清中miR-151a-3p呈负相关(r=-0.951,P<0.001)、与miR-1285-3p呈正相关(r=0.835,P<0.001);彩色多普勒超声检测的AUC为0.729,血清miR-151a-3p检测为0.707,血清miR-1285-3p检测为0.629,三者联合为0.898。结论彩色多普勒超声联合miR-151a-3p、miR-1285-3p对结核性胸膜炎患者的诊断,与单一检测相比更全面、更有效、更客观,可以更有针对性地制定治疗方法,达到精准治疗。Objective To study the diagnostic value of color Doppler ultrasound combined with miR-151a-3p and miR-1285-3p in patients with tuberculous pleurisy.Methods A total of 100 patients with tuberculous pleurisy who visited Henan Chest Hospital from March 2022 to March 2023 were selected as TP group,and 100 healthy control group as CO group.Color doppler ultrasound and miR-151a-3p and miR-1285-3p detection were performed in the two groups,respectively,and the detection results of the two groups were evaluated and analyzed.Results Compared with CO group,PSV in TP group was significantly increased(P<0.05),RI was significantly decreased(P<0.05).Compared with CO group,the expression of miR-151a-3p in serum of TP group was significantly increased,and the expression of miR-1285-3p was significantly decreased(P<0.05).PSV was positively correlated with miR-151a-3p in serum(r=0.937,P<0.001)and negatively correlated with miR-1285-3p in serum(r=-0.835,P<0.001).RI was negatively correlated with miR-151a-3p in serum(r=-0.951,P<0.001),and positively correlated with miR-1285-3p(r=0.835,P<0.001).The AUC for color Doppler ultrasound detection was 0.729,that for serum miR-151a-3p detection was 0.707,that for serum miR-1285-3p detection was 0.629,and that for the combination of the three was 0.898.Conclusion Color Doppler ultrasound combined with miR-151a-3p and miR-1285-3p in the diagnosis of patients with tuberculous pleurisy is more comprehensive,more effective and more objective than single detection,which can make more targeted treatment methods and achieve accurate treatment.

关 键 词：彩色多普勒超声 miR-151a-3p miR-1285-3p 结核性胸膜炎 诊断价值 

分 类 号：R445[医药卫生—影像医学与核医学]