机构地区:[1]湖北省黄石市中心医院医学检验科,湖北黄石435000 [2]肾脏疾病发生与干预湖北省重点实验室,湖北黄石435000 [3]湖北省黄石市中心医院全科医学科,湖北黄石435000
出 处:《检验医学与临床》2024年第3期304-307,312,共5页Laboratory Medicine and Clinic
基 金:湖北省黄石市医疗卫生科技计划项目(2019A02)。
摘 要:目的分析黄石地区住院儿童人偏肺病毒(HMPV)感染的流行病学特征及临床特点。方法回顾性分析2022年1月1日至12月31日黄石市中心医院收治的236例HMPV感染患儿的临床资料。按照病原菌感染类型和数量分为单纯HMPV感染组、混合病毒感染组和合并细菌感染组。比较各组患儿流行病学特征及临床特点。结果在236例HMPV感染患儿中,单纯HMPV感染143例(单纯HMPV感染组),占60.59%(143/236);合并其他病毒感染46例(混合病毒感染组),占19.49%;合并细菌感染47例(合并细菌感染组),占19.92%(47/236)。>1~3岁患儿HMPV感染数量最多,占55.51%(131/236)。合并细菌感染组喘息及肺炎患儿比例明显高于单纯HMPV感染组和混合病毒感染组(P<0.05)。合并细菌感染组天冬氨酸氨基转移酶、丙氨酸氨基转移酶水平及白细胞计数、淋巴细胞百分数、淋巴细胞计数、单核细胞计数均高于单纯HMPV感染组和混合病毒感染组(P<0.05)。HMPV感染构成比春季[61.44%(145/236)]显著高于冬季[25.00%(59/236)]、夏季[9.32%(22/236)]和秋季[4.24%(10/236)]。结论HMPV是引起儿童急性呼吸道感染的重要病原体之一,HMPV合并其他病原体感染可能增加儿童罹患肺炎的风险,>1~3岁患儿HMPV感染数量最多,春季是HMPV感染的高峰期。Objective To analyze the clinical features and epidemiology of human metapneumovirus(HMPV)infection in hospitalized children in Huangshi area.Methods Clinical data of 236 children with HMPV,who were enrolled in Huangshi Central Hospital from January 1st to December 31st 2022,were analyzed retrospectively,and divided into simple HMPV infection group,virus co-infection group and bacterial co-infection group according to the different types and numbers of pathogenic bacteria infection.The epidemiological features and clinical characteristics among the three groups were compared.Results Among the 236 HMPV-infected children,there were 143 cases of simple HMPV infection(simple HMPV infection group),accounting for 60.59%(143/236);46 cases of combined other viral infections(virus co-infection group),accounting for 19.49%;and 47 cases of combined bacterial infections(bacterial co-infection group),accounting for 19.92%(47/236).The highest number of children with HMPV infection was found in the children with>1-3 years old,accounting for 55.51%(131/236).The proportions of children with wheezing and pneumonia in the bacterial co-infection group were significantly higher than those in the simple HMPV infection group and virus co-infection group(P<0.05).The levels of aspartate aminotransferase and alanine aminotransferase,white blood cell count,lymphocyte percentage,lymphocyte count and monocyte count in the bacterial co-infection group were higher than those in the simple HMPV infection group and virus co-infection group(P<0.05).The propotion of HMPV infection of HMPV in spring[61.44%(145/236)]was significantly higher than that in winter[25.00%(59/236)],summer[9.32%(22/236)]and autumn[4.24%(10/236)].Conclusion HMPV is one of the important pathogens causing acute respiratory infection in children,which may increase the risk of pneumonia in children.The highest number of children with HMPV infection is in the children with>1-3 years old,and the spring is the peak time for HMPV infection.
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