外周血干细胞采集过程中改良补钙通道的应用  

Application of modified calcium channels in peripheral blood stem cell collection

作　　者：仝雪娟 樊凤艳 刘丽聪 周菁 TONG Xuejuan;FAN Fengyan;LIU Licong;ZHOU Jing(Department of Blood Transfusion,Beijing Ludaopei Hematology Hospital,Beijing 101300,China;Department of Clinical Laboratory,Air Force Specialty Medical Center,Beijing 100080,China)

机构地区：[1]北京陆道培血液病医院输血科,北京101300 [2]空军特色医学中心临床检验科,北京100080

出　　处：《检验医学与临床》2024年第3期379-382,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨在外周血干细胞(PBSC)采集过程中使用改良补钙通道进行钙剂补充在临床应用的可行性。方法选取2021年4—12月在北京陆道培血液病医院进行PBSC采集的供者220例作为研究对象,其中男166例,女54例,随机分为对照组(109例)和试验组(111例)。对照组在采集开始后建立第三条静脉通道进行钙剂补充,试验组在回血端接入补钙通道。对比两组供者低钙血症发生情况、采集后血钙水平及PBSC采集质量。结果对照组供者低钙血症发生率(16.51%)与试验组(17.12%)比较,差异无统计学意义(P>0.05);女性供者低钙血症发生率为29.63%(16/54),明显高于男性供者的12.65%(21/166),差异有统计学意义(χ^(2)=8.396,P=0.004)。结论PBSC采集过程中使用改良方式进行补钙可以达到有效补钙的目的,有助于保证PBSC采集质量,减轻供者痛苦。Objective To investigate the clinical application of calcium supplementation with modified calcium channel in peripheral blood stem cell(PBSC)collection.Methods A total of 220 donors who underwent PBSC collection from April to December 2021 in Beijing Lu Daopei Hematology Hospital were selected and randomly divided into control group(109 donors)and the experimental group(111 donors),including 166 cases of male donors and 54 cases of female donors.A third venous channel was established for calcium supplementation at the beginning of the collection in the control group,and a calcium supplementation channel was accessed at the blood return end in the experimental group.The incidence of hypocalcemia,post-collection blood calcium levels and quality of PBSC collection in two groups were compared.Results The incidences of hypocalcemia in the control group(16.51%)and the experimental group(17.12%)had no statistically significant difference(P>0.05).The incidence of hypocalcemia in female donors was 29.63%(16/54),which was significantly higher than 12.65%(21/166)of the male donors,with statistically significant difference(χ^(2)=8.396,P=0.004).Conclusion The application of modified method of calcium supplementation in PBSC collection can achieve the purpose of effective calcium supplementation,improve collection efficiency and alleviate the pain of donors.

关 键 词：干细胞采集 补钙 静脉 低钙血症 高钙血症 

分 类 号：R473[医药卫生—护理学]