益肾五苓汤联合血液透析治疗尿毒症52例  

Yishen Wuling Decoction Joined with Hemodialysis in Treating 52 Cases of Uremia

作　　者：赵紫杰 张坤[1] 余冠华[1] 龚睿琼 王雀 宋世超 ZHAO Zijie;ZHANG Kun;YU Guanghua;GONG Ruiqiong;WANG Que;SONG Shichao(Taihe Hospital of Traditional Chinese Medicine,Taihe 236608,China)

机构地区：[1]太和县中医院,安徽太和236608

出　　处：《西部中医药》2024年第2期145-148,共4页Western Journal of Traditional Chinese Medicine

基　　金：2018年度安徽高校自然科学研究项目(KJ2018C0528)。

摘　　要：目的:观察益肾五苓汤联合血液透析治疗尿毒症的临床疗效。方法:选取104例进行血液透析治疗的尿毒症患者,按就诊顺序进行分组,对照组仅进行血液透析治疗,观察组在进行血液透析的同时服用益肾五苓汤。对比两组临床治疗效果、肾功能、疼痛程度视觉模拟评分法(visual analogue score,VAS)评分、症状积分及血红蛋白(hemoglobin,Hb)、血细胞比容(hematocrit,HCT)、总蛋白(total protein,TP)水平。结果:总有效率观察组[92.3%(48/52)]高于对照组[78.8%(41/52)](P<0.05)。治疗前两组肌酐清除率(creatinine clearance rate,Ccr)、24 h尿蛋白量、尿素氮(blood urea nitrogen,BUN)及血清肌酐(serum creatinine,SCr)水平比较,差异无统计学意义(P>0.05),治疗后水平观察组Ccr明显高于对照组,SCr、24 h尿蛋白量、BUN水平低于对照组(P<0.05)。VAS评分及症状积分治疗前两组比较,差异无统计学意义(P>0.05),治疗后观察组均明显降低(P<0.05),且低于对照组(P<0.05)。Hb、HCT、TP水平治疗前两组比较,差异无统计学意义(P>0.05),治疗后观察组均明显升高(P<0.05),且高于对照组(P<0.05)。结论:在尿毒症患者血液透析时,应用益肾五苓汤可提升临床疗效,减轻患者透析过程中的疼痛程度,调节肾功能及Hb、HCT、TP水平。Objective:To observe clinical effects of Yishen Wuling decoction and hemodialysis in the treatment of uremia.Methods:All 104 patients who accepted hemodialysis were chosen and grouped according to the admission order,the control group was treated by hemodialysis only,and the observation group took Yishen Wuling decoction and hemodialysis.To compare clinical therapeutic effects,renal function,VAS scores,syndrome integrals and the levels of Hb,HCT and TP between both groups.Results:Total effective rate of the observation group was[92.3%(48/52)],higher than[78.8%(41/52)]of the control group(P<0.05).The difference had no statistical meaning in the levels of Ccr,24h urine protein,BUN and SCr before the treatment between both groups(P>0.05),after the treatment,the observation group was noticeably higher than the control group in the levels of Ccr,lower than the control group in the levels of SCr,24h urine protein and BUN(P<0.05).The difference had no statistical meaning in VAS scores,syndrome integrals before the treatment between both groups(P>0.05),after the treatment,the decrease of the observation group was more remarkable(P<0.05),and lower than that of the control group(P<0.05).The difference had no statistical meaning in the levels of Hb,HCT and TP before the treatment between both groups(P>0.05),after the treatment,the increase of the observation group were more noticeable(P<0.05),and higher than that of the control group(P<0.05).Conclusion:The application of Yishen Wuling decoction could raise clinical effects,relieve pain degrees in the course of hemodialysis,regulate renal function,the levels of Hb,HCT,TP when the patients undergo hemodialysis.

关 键 词：尿毒症 益肾五苓汤 血液透析 肌酐 24 h尿蛋白量 尿素氮 

分 类 号：R459.5[医药卫生—治疗学]