白癜风患者与健康体检者全血微量元素比较  

Comparison of trace elements in whole blood between patients with vitiligo and healthy subjects

作　　者：吴润东 陈双双[1] 李捷[1] WU Rundong;CHEN Shuangshuang;LI Jie(Department of Central Laboratory,the Second Affiliated Hospital of Henan University of Science and Technology,Henan Province,Luoyang471000,China)

机构地区：[1]河南科技大学第二附属医院中心实验室,河南洛阳471000

出　　处：《中国当代医药》2024年第3期143-146,共4页China Modern Medicine

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20191252)。

摘　　要：目的分析比较健康体检者与白癜风患者全血微量元素的差异,从而探究微量元素对于白癜风发病的影响。方法选取2022年8月至2023年6月河南科技大学第二附属医院皮肤科收治的29例白癜风患者作为白癜风组;选取同期的健康人群53例作为健康组。利用Agilent 7850电感耦合等离子体质谱仪检测全血中十种微量元素(钙、镁、铁、铜、锌、铅、硒、钼、锰、铬)的含量,统计两组微量元素差异情况。结果健康组铜元素浓度高于白癜风组,差异有统计学意义(P<0.05)。两组的其余微量元素(钙、镁、铁、锌、铅、硒、钼、锰、铬)比较,差异无统计学意义(P>0.05)。结论白癜风患者相比健康体检者全血中铜元素含量降低,证明铜元素与白癜风的发病机制具有重要关系;而钙、镁、铁、锌、铅、硒、钼、锰、铬9种微量元素与白癜风的发病没有相关联系,本研究为国内微量元素与白癜风发病机制联系的研究提供了重要的数据支撑,扩展了相关检验数据统计分析量,为白癜风的临床治疗提供了重要依据。Objective The differences between vitiligo patients and healthy subjects were evaluated,so as to explore the influence of trace elements on the pathogenesis of vitiligo.Methods A total of 29 patients with vitiligo and 53 healthy physical examination subjects admitted to Department of Central Laboratory,the Second Affiliated Hospital of Henan University of Science and Technology from August 2022 to June 2023 were selected as the study objects.Agilent 7850 inductively coupled plasma mass spectrometer was used to detect ten trace elements(calcium,magnesium,iron,copper,zinc,lead,selenium,molybdenum,manganese,chromium)in whole blood,and the difference between the two groups of trace elements was analyzed.Results The concentration of copper in healthy group was higher than that in vitiligo group,and the difference was statistically significant(P<0.05).There were no significant differences in other trace elements(calcium,magnesium,iron,zinc,lead,selenium,molybdenum,manganese and chromium)between the two groups(P>0.05).Conclusion Compared with healthy patients,the content of copper in vitiligo patients was reduced,which proved that copper had have something to do with the pathogenesis of vitiligo.There were no significant correlation between calcium,magnesium,iron,zinc,lead,selenium,molybdenum,manganese,chromium and the incidence of vitiligo.This study provides important data support for domestic research on the relationship between trace elements and the pathogenesis of vitiligo,expands the statistical analysis of relevant test data,and provides an important basis for clinical treatment of vitiligo.

关 键 词：白癜风 微量元素 铜 健康体检 全血 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]