分期“十字灸”疗法治疗寒凝血瘀型原发性痛经临床观察  

Clinical Observation of Staged"Cross Moxibustion"Therapy for Primary Dysmenorrhea with Syndrome of Cold Congeal and Blood Stasis

作　　者：庄海娜 邢利威 何喆 徐金龙 梅瑞 杨泽冠 李育红 赵荣 ZHUANG Haina;XING Liwei;HE Zhe;XU Jinlong;MEI Rui;YANG Zeguan;LI Yuhong;ZHAO Rong(Yunnan University of Chinese Medicine,Kunming,Yunnan,China,650500;Chuxiong Yi Autonomous Prefecture Hospital of Traditional Chinese Medicine,Chuxiong,Yunnan,China,675000;Yunnan Maternal and Child Health Hospital,Kunming,Yunnan,China,650051;Yunnan Hospital of Integrated Traditional Chinese and Western Medicine,Kunming,Yunnan,China,650000;Dali Nursing Vocational College,Dali,Yunnan,China,671000)

机构地区：[1]云南中医药大学,云南昆明650500 [2]楚雄彝族自治州中医医院,云南楚雄675000 [3]云南省妇幼保健院,云南昆明650051 [4]云南省中西医结合医院,云南昆明650000 [5]大理护理职业学院,云南大理671000

出　　处：《河南中医》2024年第2期280-284,共5页Henan Traditional Chinese Medicine

基　　金：“兴滇人才支持计划”名医专项项目(YNWR-MY-2018-052);云南省科技厅应用基础研究联合重点项目(2019FF002-004);楚雄医学高等专科学校-校本课题项目(2020YYXM04)。

摘　　要：目的:观察分期“十字灸”疗法治疗寒凝血瘀型原发性痛经(primary dysmenorrhea,PD)的疗效。方法:选取寒凝血瘀型PD患者72例,按照随机数字表法分为十字灸组和布洛芬组各36例。布洛芬组在月经来潮疼痛时口服布洛芬缓释胶囊治疗,十字灸组给予分期“十字灸”疗法治疗。观察两组治疗前后视觉模拟评分(visual analogue score,VAS)、血清前列腺素F2α(prostaglandin F2α,PGF2α)变化情况及临床疗效。结果:十字灸组治疗后PGF2α水平低于布洛芬组,差异具有统计学意义(P<0.05);十字灸组治疗后及随访VAS评分均低于布洛芬组,差异具有统计学意义(P<0.05);布洛芬组有效率为69.4%,十字灸组有效率为91.7%,十字灸组有效率高于布洛芬组,差异具有统计学意义(P<0.05)。结论:分期“十字灸”疗法治疗寒凝血瘀型原发性痛经近期、远期疗效均优于布洛芬缓释胶囊,其作用机制可能与通过减少子宫内膜产生和释放PGF2α相关。Objective:To observe the clinical efficacy of staged"cross moxibustion"therapy on primary dysmenorrhea(PD)with syn-drome of cold congeal and blood stasis.Methods:A total of 72 PD patients with syndrome of cold congeal and blood stasis were selected and divided into the cross moxibustion group and the ibuprofen group according to the random number table method,with 36 cases in each group.The ibuprofen group was treated with Ibuprofen Sustained-Release Capsules when menstrual pain occurred,while the cross moxibustion group was treated with staged"cross moxibustion"therapy.The changes in visual analogue score(VAS),serum prosta-glandin F2α(PGF2α)before and after treatment and clinical efficacy of the two groups were observed.Results:After treatment,the PGF2αlevel in the cross moxibustion group was lower than that in the ibuprofen group,with statistically significant difference(P<0.05);the VAS score in the cross moxibustion group was lower than that in the ibuprofen group and follow-up,with statistically signifi-cant difference(P<0.05);the effective rate in the ibuprofen group was 69.4%,and that in the cross moxibustion group was 91.7%,with statistically significant difference(P<0.05).Conclusion:The short-term and long-term efficacy of staged"cross moxibustion"therapy for PD with syndrome of cold congeal and blood stasis is better than that of Ibuprofen Sustained-Release Capsules,and its mech-anism may be related to reducing the production and release of PGF2αin the endometrium.

关 键 词：原发性痛经 寒凝血瘀证 分期“十字灸”疗法 布洛芬缓释胶囊 前列腺素F2Α 

分 类 号：R271.113[医药卫生—中医妇科学]