多囊卵巢综合征患者IL-23/IL-17轴相关因子水平的变化及临床意义  

Changes and clinical significance of IL-23/IL-17 axis-related factors in patients with polycystic ovary syndrome

作　　者：马爱华 张亚丽 赵贝 耿文君 李红丽 MA Ai-hua;ZHANG Ya-li;ZHAO Bei;GENG Wen-jun;LI Hong-li(Department of Gynaecology,Henan Provincial Hospital of Reproductive Medicine,Zhengzhou 475000,Henan,CHINA;Reproductive Medicine Center,Henan Provincial Hospital of Reproductive Medicine,Zhengzhou 475000,Henan,CHINA)

机构地区：[1]河南省生殖妇产医院妇科,河南郑州475000 [2]河南省生殖妇产医院生殖医学中心,河南郑州475000

出　　处：《海南医学》2024年第2期244-248,共5页Hainan Medical Journal

基　　金：河南省属科研院所基本科研业务费专项资金项目(编号:JBKY2023006)。

摘　　要：目的 探讨多囊卵巢综合征(PCOS)患者白介素(IL)-23/IL-17轴相关因子水平的变化及其临床意义。方法 选取2022年3月至2023年3月河南省生殖妇产医院收治的102例PCOS患者作为观察组,遵循1∶1分配原则,纳入同期102例健康育龄女性作为对照组。比较两组受检者以及观察组不同特征患者的血清IL-23、IL-17、IL-6、IL-22水平,采用Spearman相关分析观察组临床特征与IL-23/IL-17轴相关因子的相关性,绘制受试者工作特征曲线(ROC)分析IL-23/IL-17轴相关因子单一或联合诊断PCOS的效能,采用相对危险度(RR)分析不同IL-23/IL-17轴相关因子表达对PCOS发病的影响。结果 观察组患者的血清IL-23、IL-17、IL-6水平分别为(60.44±18.18) pg/mL、(240.02±72.21) pg/mL、(15.56±4.67) pg/mL,明显高于对照组的(41.89±12.57) pg/mL、(167.68±50.14) pg/mL、(10.80±3.21) pg/mL,IL-22水平为(25.12±7.50) pg/mL,明显低于对照组的(32.87±9.85) pg/mL,差异均有统计学意义(P<0.05);肥胖组、胰岛素抵抗组、高血激素血症组患者的血清IL-23、IL-17、IL-6水平明显高于非肥胖组、非胰岛素抵抗组、非高雄激素血症组,IL-22水平明显低于非肥胖组、非胰岛素抵抗组、非高雄激素血症组,差异均有统计学意义(P<0.05);经Spearman相关分析结果显示,胰岛素抵抗、肥胖、高雄激素血症与血清IL-23、IL-17、IL-6呈正相关(P<0.05),与IL-22呈负相关(P<0.05);经ROC分析结果显示,IL-23、IL-17、IL-6、IL-22联合诊断PCOS效能的AUC明显优于各指标单一诊断;IL-23、IL-17、IL-6高表达患者PCOS发病风险是低表达患者的3.428倍、2.150倍、2.354倍,IL-22低表达患者PCOS发病风险是高表达的2.996倍。结论 PCOS患者血清IL-23/IL-17轴相关因子差异表达,且与患者肥胖、胰岛素抵抗、高血激素血症密切相关,上述有关因子联合诊断PCOS具有较好效能。Objective To investigate the changes and clinical significance of interleukin(IL)-23/IL-17 axis-re-lated factors in patients with polycystic ovary syndrome(PCOS).Methods A total of 102 patients with PCOS admitted to the Henan Provincial Hospital of Reproductive Medicine from March 2022 to March 2023 were selected as the obser-vation group,and 102 healthy reproductive-age women were included as the control group.The levels of serum IL-23,IL-17,IL-6,and IL-22 in the observation group were compared between the two groups and among patients with differ-ent characteristics.Spearman correlation analysis was used to investigate the correlation between clinical characteristics and IL-23/IL-17 axis-related factors in the observation group.The receiver operating characteristic(ROC)curve was used to analyze the efficacy of single or combined diagnosis of PCOS using IL-23/IL-17 axis-related factors.The rela-tive risk(RR)was used to analyze the impact of different IL-23/IL-17 axis-related factor expressions on the pathogene-sis of PCOS.Results The serum levels of IL-23,IL-17,and IL-6 in the observation group were(60.44±18.18)pg/mL,(240.02±72.21)pg/mL,and(15.56±4.67)pg/mL,respectively,which were significantly higher than(41.89±12.57)pg/mL,(167.68±50.14)pg/mL,and(10.80±3.21)pg/mL in the control group;the level of IL-22 was(25.12±7.50)pg/mL,which was significantly lower than(32.87±9.85)pg/mL in the control group;the differences were statistically significant(P<0.05).The serum levels of IL-23,IL-17,and IL-6 in the obesity group,insulin resistance group,and hyperandrogenism group were significantly higher than those in the non-obesity group,non-insulin resistance group,and non-hyperan-drogenism group,respectively;the level of IL-22 was significantly lower than that in the non-obesity group,non-insulin resistance group,and non-hyperandrogenism group;the differences were statistically significant(P<0.05).Spearman analysis showed that insulin resistance,obesity,and hyperandrogenism were positively correlated with serum IL-23,

关 键 词：多囊卵巢综合征 白介素-23 白介素-17 白介素-6 白介素-22 胰岛素抵抗 相关性 

分 类 号：R711.75[医药卫生—妇产科学]