僵人综合征2例报告并文献分析  

Stiff-person syndrome:a report of two cases and literatures analysis

作　　者：童伟芳 徐鸣明[2] 汪锡金 TONG Weifang;XU Mingming;WANG Xijin(Department of Neurology,Tongji Hospital of Tongji University,Shanghai 200065,China;Department of Neurology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University of Medicine,Shanghai 200092,China)

机构地区：[1]同济大学附属同济医院神经内科,上海200065 [2]上海交通大学医学院附属新华医院神经内科,上海200092

出　　处：《中国医药导报》2023年第35期185-188,共4页China Medical Herald

基　　金：国家自然科学基金面上项目(82271227);国家重点研发计划项目(2022YFF1202804);山东省重点研发计划项目(2020CXGC011301)。

摘　　要：僵人综合征(SPS)主要临床表现为波动性、进行性躯干和近端肢体的僵硬,伴痛性痉挛。随着病程进展,SPS患者易出现永久性骨骼异常,最终导致无法行走和残疾。但大多数患者早期可通过药物治疗得到改善。因此,早期诊断、早期治疗对预防或延缓该疾病的进展至关重要。但SPS临床表现复杂多变,给医务工作者带来了巨大的挑战。因此,医务人员需进一步加强相关理论知识的学习,提高对该病的认识。本文报道了2023年在同济大学附属同济医院就诊的2例SPS患者的病历资料,其中1例是以惊吓为诱因且合并桥本甲状腺炎的SPS患者,另1例为合并胸腺瘤的SPS患者。通过探讨该2例特殊SPS的临床特点,有助于提高医务工作者早期识别和诊断,减少误诊、误治。Stiff-person syndrome(SPS)is characterized by fluctuating,progressive stiffness of the trunk and proximal limbs,accompanied by painful spasticity.With the progression of the disease,SPS patients are prone to permanent skeletal abnormalities,eventually leading to inability to walk and disability.However,most patients can be improved by medical treatment in the early stage.Therefore,early diagnosis and treatment are essential to prevent or delay the progression of the disease.However,the clinical manifestations of SPS are complex and variable,which brings great challenges to medical workers.Therefore,doctors need to further strengthen the study of relevant theoretical knowledge and improve the understanding of this disease.This paper reports the medical records of two cases with SPS treated in Tongji Hospital of Tongji University in 2023.Among them,one was SPS patient with Hashimoto thyroiditis,and the other was SPS patient with thymoma.By discussing the clinical characteristics of the two special SPS cases,it is helpful to improve the early recognition and diagnosis of doctor and reduce misdiagnosis and mistreatment.

关 键 词：僵人综合征 临床症状 桥本甲状腺炎 胸腺瘤 

分 类 号：R593.2[医药卫生—内科学]