CagA阳性幽门螺杆菌感染与中年无症状人群CIMT相关性研究  

Association between CagA-antibody-positive helicobacter pylori infection and carotid intima-media thickness in middle-aged asymptomatic population

作　　者：王明虎 苗利辉 刘景新 仲玉[4] WANG Ming-hu;MIAO Li-hui;LIU Jing-xin;ZHONG Yu(Department of Emergency,Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China;Department of Geriatrics,Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China;Departments of Radiology,Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China;Center of Model Worker Health Management,Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China)

机构地区：[1]首都医科大学附属北京康复医院急诊科,北京100144 [2]首都医科大学附属北京康复医院老年康复中心,北京100144 [3]首都医科大学附属北京康复医院放射科,北京100144 [4]首都医科大学附属北京康复医院劳模健康管理中心,北京100144

出　　处：《河北医科大学学报》2024年第2期130-134,共5页Journal of Hebei Medical University

基　　金：首都医科大学附属北京康复医院科技发展专项(2022-071)。

摘　　要：目的探讨细胞毒素相关蛋白A(cytotoxin-associated protein A,CagA)阳性Hp感染与中年无症状人群颈动脉粥样硬化(carotid atherosclerosis,CAS)的相关性。方法选取在我院就诊的CAS患者578例作为CAS组,选取无CAS患者578例作为对照组,比较2组CagA阳性Hp感染比例,并作Logistic回归分析。比较CagA阳性Hp感染患者与CagA阴性患者颈动脉内-中膜厚度(carotid intima-media thick-ness,CIMT)。结果CAS组CagA阳性Hp感染患者比例高于对照组(P<0.05)。CagA阳性Hp感染是CAS的独立危险因素(OR=1.813,95%CI:1.379~2.384,P<0.05)。CagA阳性Hp感染患者CIMT大于CagA阴性患者(t=28.046,P<0.05)。结论在中年无症状人群中,CagA阳性Hp感染是CAS的独立危险因素,CagA阳性Hp感染患者CIMT大于CagA阴性Hp感染患者。因此,CagA阳性Hp感染与CAS的发生、发展有关。Objective To examine the association between CagA-antibody-positive helicobacter pylori(Hp)infection and carotid atherosclerosis(CAS)in middle-aged asymptomatic population.Methods A total of 578 CAS patients treated in our hospital were selected for this study,and 578 patients without CAS were selected as the control group.CagA-antibody-positive Hp infection was compared between two groups,and logistic regression analysis was conducted.Carotid intima-media thickness(CIMT)was compared between patients with CagA-antibody-positive Hp infection and those with CagA-antibody-negative Hp infection.Results The CAS group had significantly higher frequency of CagA-antibody-positive Hp infection than the controls(P<0.05).CagA-antibody-positive Hp infection was an independent risk factors for CAS(OR=1.813,95%CI:1.379-2.384,P<0.05).CIMT was significantly greater in patients with CagA-antibody-positive Hp infection than in those with CagA-antibody-negative Hp infection(t=28.046,P<0.05).Conclusion In middle-aged asymptomatic population,CagA-antibody-negative Hp infection is an independent risk factor for CAS.The levels of CIMT in patients with CagA-antibody-positive Hp infection are significantly higher than those of patients with CagA-antibody-negative Hp infection.Thus,CagA-antibody-positive Hp infection has been implicated in the development and progression of CAS.

关 键 词：幽门螺杆菌 颈动脉粥样硬化 细胞毒素相关蛋白A 

分 类 号：R714.252[医药卫生—妇产科学]