血清抵抗素对老年糖尿病患者伴发抑郁的影响  

Effect of serum resistin on depression in elderly patients with diabetes

作　　者：安广华 陈晔 杨帆 乔彩霞 高金娥 AN Guang-hua;CHEN Ye;YANG Fan;QIAO Cai-xia;GAO Jin-e(Geriatrics Department,People′s Hospital of Inner Mongolia Autonomous Region,Hohhot 010010,China;Department of Endocrinology,People′s Hospital of Inner Mongolia Autonomous Region,Hohhot 010010,China;Department of Mental Health,People′s Hospital of Inner Mongolia Autonomous Region,Hohhot 010010,China)

机构地区：[1]内蒙古自治区人民医院老年医学科,内蒙古呼和浩特010010 [2]内蒙古自治区人民医院内分泌科,内蒙古呼和浩特010010 [3]内蒙古自治区人民医院精神卫生科,内蒙古呼和浩特010010

出　　处：《河北医科大学学报》2024年第2期236-241,共6页Journal of Hebei Medical University

基　　金：内蒙古自然科学基金项目(2021LHMS08061)。

摘　　要：目的探究血清抵抗素对老年糖尿病患者伴发抑郁的影响。方法本研究选取老年糖尿病患者114例作为研究对象,采用老年抑郁评估量表(The Geriatric Depression Scale-15,GDS-15)评估抑郁情况,以CDS-15评分>4分视为抑郁,比较是否伴发抑郁的老年糖尿病患者血清抵抗素水平;以血清抵抗素水平四分位数分为4组,检验血清抵抗素水平对老年糖尿病患者伴发抑郁的影响;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析血清抵抗素预测患者伴发抑郁的价值。结果114例老年糖尿病患者中伴发抑郁26例,发生率为22.81%。抑郁组血清抵抗素水平明显高于无抑郁组(P<0.05)。不同血清抵抗素水平分组血清三酰甘油(triglyceride,TG)水平比较差异有统计学意义(P<0.05)。经点二列相关性分析显示,老年糖尿病患者伴发抑郁与血清抵抗素水平呈正相关(P<0.05);经双变量Pearson相关性结果显示,老年糖尿病患者血清抵抗素水平与TG、糖化血红蛋白水平呈正相关(P<0.05)。经Logistic回归分析显示,血清抵抗素、TG和糖化血红蛋白水平均为老年糖尿病患者伴发抑郁的影响因素(P<0.05)。入组时血清抵抗素水平预测老年糖尿病患者伴发抑郁的曲线下面积(area under curve,AUC)为0.808。结论血清抵抗素水平可影响老年糖尿病患者伴发抑郁风险,血清抵抗素水平越高,患者伴发抑郁风险越高,可作为辅助预测患者伴发抑郁的指标。Objective To explore the effect of serum resistin on depression in elderly patients with diabetes.Methods In this study,114 elderly patients with diabetes were selected as the subjects.The Geriatric Depression Scale 15(GDS-15)was used to assess the depression.The CDS-15 score>4 was regarded as depression,and the serum resistin level of elderly diabetic patients with depression was compared.The quartile of serum resistin level was divided into 4 groups to test the effect of serum resistin level on depression in elderly patients with diabetes.Receiver operating characteristic(ROC)curve was drawn to analyze the value of serum resistin in predicting depression in patients.Results Among 114 elderly patients with diabetes,26 were accompanied by depression,with an incidence of 22.81%.The serum resistin levels in the depression group were significantly higher than those in the non-depression group(P<0.05).There was a statistically significant difference in serum triglyceride(TG)levels among groups with different levels of serum resistin(P<0.05).The binary correlation analysis showed that depression in elderly patients with diabetes was positively correlated with serum resistin level(P<0.05).The results of bivariate Pearson correlation showed that the serum resistin level in elderly patients with diabetes was positively correlated with TG and HbA1c levels(P<0.05).Logistic regression analysis showed that serum resistin,TG and glycosylated hemoglobin levels were the influencing factors of depression in elderly patients with diabetes(P<0.05).The area under curve(AUC)of the serum resistin level in predicting depression in elderly diabetic patients at the time of enrollment was 0.808.Conclusion The level of serum resistin can affect the risk of depression in elderly patients with diabetes.The higher the level of serum resistin,the higher the risk of depression in patients with diabetes,which can be used as an auxiliary indicator to predict the risk of depression in patients with diabetes.

关 键 词：糖尿病 老年人 抑郁 抵抗素 

分 类 号：R587.1[医药卫生—内分泌]