舒洛地特联合卡托普利对糖尿病肾病患者微炎症状态和免疫功能的影响  

Effects of Sulodexide combined with Captopril on microinflammatory state and immune function in patients with diabetic nephropathy

作　　者：张文博[1] 郭宇[1] 胡建龙 ZHANG Wenbo;GUO Yu;HU Jianlong(Department of Endocrinology of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000 Henan,China)

机构地区：[1]河南科技大学第一附属医院内分泌科,河南洛阳471000

出　　处：《中国民康医学》2024年第2期18-21,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨舒洛地特联合卡托普利对糖尿病肾病患者微炎症状态和免疫功能的影响。方法:选取2020年3月至2022年4月该院收治的86例糖尿病肾病患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各43例。对照组口服卡托普利片治疗,研究组在对照组基础上口服舒洛地特软胶囊治疗,治疗3个月后,比较两组临床疗效,治疗前后肾功能指标[24 h尿蛋白定量(24hUP)、血肌酐(SCR)、血尿素氮(BUN)]水平、血清炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、免疫功能指标[免疫球蛋白(Ig)A、IgM]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,研究组SCR、BUN、24hUP、CRP、IL-6水平均低于对照组,IgA、IgM水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:舒洛地特联合卡托普利治疗糖尿病肾病患者效果显著,能够提高肾功能和免疫功能,减轻微炎症状态,效果优于单用卡托普利治疗。Objective:To investigate effects of Sulodexide combined with Captopril on microinflammatory state and immune function in patients with diabetic nephropathy.Methods:A prospective study was conducted on 86 patients with diabetic nephropathy admitted to this hospital from March 2020 to April 2022.They were divided into study group and control group according to the random number table method,43 cases in each group.The control group was treated with Captopril tablets,while the study group was treated with Sulodexide soft capsules on the basis of that of the control group.After 3 months of treatment,the clinical efficacy,the renal function indexes[24 h urine protein quantification(24hUP),serum creatinine(SCR),blood urea nitrogen(BUN)]levels,the serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]levels,the immune function indexes[immunoglobulin(Ig)A,IgM]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of SCR,BUN,24hUP,CRP and IL-6 in the study group were lower than those in the control group,the levels of IgA and IgM were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Sulodexide combined with Captopril is effective in the treatment of the patients with diabetic nephropathy,which can improve the renal function,reduce the micro-inflammatory state,and improve the immune function.Moreover,it is superior to single Captopril treatment.

关 键 词：舒洛地特 卡托普利 糖尿病肾病 微炎症状态 免疫功能 

分 类 号：R692.9[医药卫生—泌尿科学]