低分子肝素钠注射液配合常规物理疗法治疗对下肢骨折术后患者凝血功能、血液流变学指标的影响  

Effect of Low Molecular Weight Heparin Sodium Injection Combined with Conventional Physiotherapy on Coagulation Function and Hemorheology in Patients with Lower Limb Fracture after Operation

作　　者：毕凌峰 BI Lingfeng(Guixi People's Hospital,Yingtan Jiangxi 335400,China)

机构地区：[1]贵溪市人民医院,江西鹰潭335400

出　　处：《药品评价》2023年第10期1263-1266,共4页Drug Evaluation

摘　　要：目的分析低分子肝素钠注射液配合常规物理疗法治疗对下肢骨折术后患者凝血功能、血液流变学指标的影响。方法选择贵溪市人民医院于2021年1月至2023年1月收治的下肢骨折患者80例,通过随机数字表法分为观察组40例和对照组40例。对照组予以常规康复疗法,观察组在对照组的基础上予以低分子肝素钠注射液配合常规物理疗法,两组患者均持续治疗2周。观察比较两组患者凝血功能[凝血酶原时间(PT)、凝血活酶时间(APTT)和D-二聚体(D-D)水平],血液流变学(血浆黏度、高切全血黏度及低切全血黏度),下肢静脉血栓及不良反应的发生情况。结果治疗后,观察组凝血功能PT(15.74±2.32)s、APTT(29.76±3.82)s水平高于对照组的(13.90±1.98)s、(26.85±3.46)s;D-D(175.67±29.88)g/L水平低于对照组的(251.43±33.47)g/L;高切全血黏度(3.98±0.24)mPs·s、低切全血黏度(8.23±0.14)mPs·s及血浆黏度(1.38±0.42)mPs·s低于对照组的(4.44±0.38)mPs·s、(9.59±0.28)mPs·s及(1.60±0.47)mPs·s,差异有统计学意义(P<0.05)。两组治疗1周及治疗2周后的下肢静脉血栓发生率比较,差异无统计学意义(P>0.05)。结论低分子肝素钠注射液配合常规物理疗法治疗下肢骨折术后患者效果显著,可有效改善患者的凝血功能和血液流变学指标,有效预防下肢静脉血栓的发生率,且安全性较高,有良好的应用价值。Objective The purpose is to analyze the effect of low molecular weight heparin sodium injection combined with conventional physical therapy on coagulation function and hemorheological indicators in postoperative patients with lower limb fractures.Methods This study used 80 patients with lower limb fractures admitted to Guixi People's Hospital from January 2021 to January 2023.They were randomly divided into an observation group(40 cases)and a control group(40 cases)using a random number table method.Both groups of patients underwent routine examinations and received basic treatment after admission.The control group received routine rehabilitation therapy.On the basis of the control group,the observation group received low molecular weight heparin sodium injection combined with routine physical therapy,both groups of patients continued treatment for 2 weeks.Observe and compare the coagulation function[prothrombin time(PT),prothrombin time(APTT),and D-dimer(D-D)levels],hemorheology(plasma viscosity,high shear whole blood viscosity,and low shear whole blood viscosity),lower limb venous thrombosis,and incidence of adverse reactions between two groups of patients.Results After 2 weeks of continuous treatment,the PT(15.74±2.32)s and APTT(29.76±3.82)s levels in the observation group were higher than those in the control group(13.90±1.98)s and(26.85±3.46)s,and the D-D(175.67±29.88)g/L levels were lower than those in the control group(251.43±33.47)g/L;the high shear whole blood viscosity(3.98±0.24)mPs.s,low shear whole blood viscosity(8.23±0.14)mPs.s,and plasma viscosity(1.38±0.42)mPs.s were lower than those of the control group(4.44±0.38)mPs.s,(9.59±0.28)mPs.s,and(1.60±0.47)mPs.s,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of lower limb venous thrombosis between the two groups(P>0.05).Conclusion Low molecular weight heparin sodium injection combined with conventional physical therapy has a significant effect on the treatment of postoper

关 键 词：下肢骨折 肝素 低分子量 物理疗法 凝血功能 血液流变学 

分 类 号：R687.3[医药卫生—骨科学]