不同剂量氨茶碱对小儿全身麻醉术后催醒效果  

Effect of Different Doses of Aminophylline on Awakening of Children after General Anesthesia

作　　者：胡荣[1] 刘华珍 游丽姗 廖美洲 李伟琼 HU Rong;LIU Huazhen;YOU Lishan;LIAO Meizhou;LI Weiqiong(Shicheng County People's Hospital,Shicheng Jiangxi 342700,China)

机构地区：[1]石城县人民医院,江西石城342700

出　　处：《药品评价》2023年第10期1267-1270,共4页Drug Evaluation

基　　金：赣州市卫生健康委员会市级科研计划项目(2022-2-224)。

摘　　要：目的探究不同剂量氨茶碱对小儿全身麻醉术后催醒效果。方法回顾性分析2020年1月至2023年6月于石城县人民医院行腹股沟疝手术的80例患儿临床资料,依据术后催醒方法不同分为A组(60例均使用氨茶碱)及C组(20例均使用等量生理盐水),再根据A组氨茶碱剂量使用不同分为A1组(1 mg/kg)、A3组(3 mg/kg)、A5组(5 mg/kg),各20例。对比各组平均动脉压(MAP),心率(HR),拔管后出室时间、苏醒时间,不良反应。结果四组不同时间点MAP、HR比较,差异无统计学意义(P>0.05)。A5组苏醒时间少于A3组、A1组及C组,差异有统计学意义(P<0.05);A1组、A3组及A5组拔管后出室时间均少于C组,差异有统计学意义(P<0.05),但A1组、A3组及A5组拔管后出室时间对比,差异无统计学意义(P>0.05)。A1组不良反应发生率最低,但四组不良反应发生率比较,差异无统计学意义(P>0.05)。结论选择5 mg/kg剂量的氨茶碱在小儿全身麻醉术后催醒中效果最佳,能够有效缩短术后苏醒时间,安全可靠,值得推广应用。Objective To explore the effect of different doses of aminophylline on awakening of children after general anesthesia.Methods The clinical data of 80 children who underwent inguinal hernia surgery in Shicheng County People's Hospital from January 2020 to June 2023 were retrospectively analyzed,and they were divided into group A(60 cases were treated with aminophylline)and group C(20 cases were treated with the same amount of normal saline)according to different postoperative awakening methods.According to the different dosage of aminophylline used in group A,they were divided into A1 group(1mg/kg),A3 group(3 mg/kg)and A5 group(5 mg/kg),with 20 cases each.The mean arterial pressure(MAP),heart rate(HR),exit time after extubation,recovery time and adverse reactions were compared.Results There was no significant difference in MAP and HR between the four groups at different time points(P>0.05).The recovery time of A5 group was shorter than that of A3 group,A1 group and C group,the difference was statistically significant(P<0.05).The exit time after extubation in groups A1,A3 and A5 was shorter than that in group C,with statistical significance(P<0.05),but there was no statistical significance in the comparison of the exit time after extubation in groups A1,A3 and A5(P>0.05).The incidence of adverse reactions in group A1 was the lowest,but there was no statistical significance in the incidence of adverse reactions among the four groups(P>0.05).Conclusion 5 mg/kg aminophylline has the best effect in children after general anesthesia,which can effectively shorten the postoperative recovery time,is safe and reliable,and is worthy of popularization and application.

关 键 词：氨茶碱 麻醉恢复期 全身麻醉 平均动脉压 麻醉深度指数 不良反应 

分 类 号：R726.1[医药卫生—儿科]