二甲双胍治疗老年2型糖尿病的效果分析  

Effect Analysis of Metformin in the Treatment of Senile Type 2 Diabetes Mellitus

作　　者：董雯丽 刘海[1] 徐永权[1] 崔腾香 Dong Wenli;Liu Hai;Xu Yongquan;Cui Tengxiang(Department of Geriatric Rehabilitation,Gansu Province Hospital Rehabilitation Center,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃省康复中心医院老年病康复科,甘肃兰州730000

出　　处：《中国社区医师》2023年第33期11-13,共3页Chinese Community Doctors

基　　金：甘肃省重点研究发展计划资助项目(编号:20YF3FA007)。

摘　　要：目的:分析二甲双胍治疗老年2型糖尿病的效果。方法:选取2022年1月-2023年4月甘肃省康复中心医院收治的100例老年2型糖尿病患者作为研究对象,依据随机数字表法分为两组,各50例。对照组应用瑞格列奈治疗,观察组应用二甲双胍治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.045)。治疗前,两组糖化血红蛋白、空腹血糖及餐后2 h血糖水平比较,差异无统计学意义(P>0.05);治疗后,两组糖化血红蛋白、空腹血糖及餐后2 h血糖水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和总胆固醇(TC)水平比较,差异无统计学意义(P>0.05);治疗后,两组LDL-C、TG、TC水平低于治疗前,且观察组低于对照组,两组HDL-C水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.037)。结论:二甲双胍在老年2型糖尿病治疗中的应用价值较高,可改善患者血糖、血脂水平,降低不良反应发生率。Objective:To analyze the effect of metformin in the treatment of senile type 2 diabetes mellitus.Methods:100 elderly patients with type 2 diabetes treated in Gansu Province Hospital Rehabilitation Center from January 2022 to April 2023 were selected as research objects and divided into two groups with 50 cases each according to random number table method.The control group was treated with repaglinide and the observation group was treated with metformin.The therapeutic effect of the two groups was compared.Results:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P=0.045).Before treatment,there was no significant difference in HBA1c,fasting blood glucose and 2 h postprandial blood glucose levels between the two groups(P>0.05).After treatment,the levels of HBA1c,fasting blood glucose and 2 h postprandial blood glucose in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and total cholesterol(TC)between the two groups(P>0.05).After treatment,the levels of LDL-C,TG and TC in two groups were lower than before treatment,and the observation group was lower than the control group,and the HDL-C level in two groups was higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.037).Conclusion:Metformin has high application value in the treatment of elderly type 2 diabetes mellitus,which can improve the level of blood glucose and lipid and reduce the incidence of adverse reactions.

关 键 词：2型糖尿病 二甲双胍 老年 血糖 

分 类 号：R587.1[医药卫生—内分泌]