沙库巴曲缬沙坦联合美托洛尔在冠心病合并慢性心力衰竭患者中的应用效果  

Application Effect of Sacubitril Valsartan Combined with Metoprolol in Patients with Coronary Heart Disease and Chronic Heart Failure

作　　者：王斌[1] Wang Bin(Occupational Disease Prevention and Control Institute of State Grid Corporation of China,Hangzhou 311600,Zhejiang Province,China)

机构地区：[1]国家电网公司职业病防治院,浙江杭州311600

出　　处：《中国社区医师》2023年第34期10-12,共3页Chinese Community Doctors

摘　　要：目的:分析冠心病合并慢性心力衰竭患者应用沙库巴曲缬沙坦联合美托洛尔的效果。方法:选取2021年1月—2022年12月国家电网公司职业病防治院收治的150例冠心病合并慢性心力衰竭患者作为研究对象,采用随机数字表法分为对照组和观察组,各75例。对照组在常规治疗基础上给予美托洛尔治疗,观察组在对照组基础上联合沙库巴曲缬沙坦治疗。比较两组心功能指标、血清指标水平与临床疗效。结果:治疗前,两组每搏输出量(SV)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)比较,差异无统计学意义(P>0.05);治疗后,两组SV、LVEF高于治疗前,且观察组高于对照组,两组LVEDD低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清可溶性ST2受体(sST2)、正五聚体蛋白3(PTX-3)、降钙素基因相关肽(CGRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组sST2、PTX-3水平低于治疗前,且观察组低于对照组,两组CGRP水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.029)。结论:沙库巴曲缬沙坦联合美托洛尔在冠心病合并慢性心力衰竭患者中的应用效果显著,可改善患者心功能和血清指标,提高临床疗效。Objective:To analyze the effect of applying sacubitril valsartan combined with metoprolol in patients with coronary heart disease and chronic heart failure.Methods:A total of 150 patients with coronary heart disease and chronic heart failure admitted to the Occupational Disease Prevention and Control Institute of State Grid Corporation of China from January 2021 to December 2022 were se‑lected as the study subjects.They were divided into control group and observation group according to random number table method,with 75 patients in each group.The control group was treated with metoprolol on the basis of routine treatment,while the observation group was treated with sacubitril valsartan on the basis of control group.The levels of cardiac function indicators and serum indicators,as well as clinical efficacy were compared between the two groups.Results:Before treatment,there was no significant difference in stroke volume(SV),left ventricular end-diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)between the two groups(P>0.05);after treatment,the SV and LVEF in the two groups were higher than those before treatment,and these indicators in the observation group were higher than those in the control group,while the LVEDD in the two groups was lower than that before treat‑ment,and this indicator in the observation group was lower than that in the control group,and the difference was statistically signifi‑cant(P<0.05).Before treatment,there was no significant difference in the levels of serum soluble ST2 receptor(sST2),pentraxin 3(PTX-3)and calcitonin gene-related peptide(CGRP)between the two groups(P>0.05);after treatment,the levels of sST2 and PTX-3 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,while the CGRP levels in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group,and the difference was statistically significant

关 键 词：沙库巴曲缬沙坦 美托洛尔 冠心病 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病] R541.4[医药卫生—内科学]