支气管镜灌洗联合大环内酯类抗生素与糖皮质激素治疗儿童重症支原体肺炎的效果分析  

Effect Analysis of Bronchoscopic Lavage Combined with Macrolide Antibiotics and Glucocorticoid in Treatment of Severe Mycoplasma Pneumoniae Pneumonia in Children

作　　者：范旻皞[1] Fan Minhao(Department of Pediatric Respiratory Medicine,Wuxi Children's Hospital,Wuxi 214000,Jiangsu Province,China)

机构地区：[1]无锡市儿童医院儿呼吸内科,江苏无锡214000

出　　处：《中国社区医师》2023年第36期28-30,共3页Chinese Community Doctors

摘　　要：目的:分析支气管镜灌洗联合大环内酯类抗生素与糖皮质激素治疗儿童重症支原体肺炎(SMPP)的效果。方法:选取2020年3月—2023年3月无锡市儿童医院收治的90例SMPP患儿作为研究对象,采用随机数字表法分为对照组与试验组,各45例。对照组采用大环内酯类抗生素联合糖皮质激素治疗,试验组在对照组基础上联合支气管镜灌洗治疗。比较两组实验室指标、症状体征消失时间、影像学恢复情况、治疗效果。结果:治疗后,两组D-二聚体、乳酸脱氢酶、C反应蛋白水平低于治疗前,且试验组低于对照组,差异有统计学意义(P<0.05)。试验组咳嗽消失时间、肺部体征消失时间、体温恢复正常时间、啰音消失时间、病灶吸收时间早于对照组,糖皮质激素治疗时间短于对照组,差异有统计学意义(P<0.001)。试验组影像学基本恢复率高于对照组,差异有统计学意义(P=0.013)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.014)。结论:支气管镜灌洗治疗SMPP的效果显著,可减轻炎性反应,缩短患儿恢复时间。Objective:To analyze the effect of bronchoscopic lavage combined with macrolide antibiotics and glucocorticoid in the treatment of pediatric severe Mycoplasma pneumoniae pneumonia(SMPP).Methods:A total of 90 children with SMPP admitted to Wuxi Children's Hospital from March 2020 to March 2023 were selected as the study subjects.They were divided into control group and test group according to random number table method,with 45 cases in each group.The control group was treated with macrolide antibiotics combined with glucocorticoid,and the test group was treated with bronchoscopic lavage on the basis of the control group.The laboratory indicators,disappearance time of symptoms and signs,imaging recovery,and treatment effect were compared between the two groups.Results:After treatment,the levels of D-dimer,lactate dehydrogenase and C-reactive protein in the two groups were lower than those before treatment,and the levels in the test group were lower than those in the control group,with a statistically significant difference(P<0.05).The disappearance time of cough,disappearance time of pulmonary signs,time of returning to normal body temperature,disappearance time of rales and lesion absorption time in the test group were earlier than those in the control group,and the duration of glucocorticoid treatment in the test group was shorter than that in the control group,with a statistically significant difference(P<0.001).The basic imaging recovery rate in the test group was higher than that in the control group,and the difference was statistically significant(P=0.013).The total effective rate of treatment in the test group was higher than that in the control group,and the difference was statistically significant(P=0.014).Conclusion:Bronchoscopic lavage in treatment of SMPP has a significant effect,and can relieve inflammatory reaction and shorten the recovery time of children.

关 键 词：支气管镜灌洗 儿童 重症支原体肺炎 大环内酯类抗生素 糖皮质激素 

分 类 号：R725.6[医药卫生—儿科]