补骨脂肝损伤实验研究及网络毒理学预测研究进展  

Liver Injury Caused by Psoraleae Fructus:A Review

作　　者：唐璇 韩佳寅[1] 潘辰[1] 张宇实[1] 梁爱华[1] TANG Xuan;HAN Jiayin;PAN Chen;ZHANG Yushi;LIANG Aihua(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2024年第2期179-189,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82192913,82174073);中国中医科学院创新基金项目(CI2021B016,CI2021A04801);中国中医科学院优秀青年科技人才项目(ZZ15-YQ-046)。

摘　　要：补骨脂是传统的无毒中药,但近年来出现了一些关于其造成药物性肝损伤的报道,使得其用药安全问题引起了社会的广泛关注。目前,仅根据动物实验和体外实验研究补骨脂肝损伤的毒性机制及相关作用靶点和有毒成分与临床出现的补骨脂药物性肝损伤实际情况存在一定的差距,这说明尚有一些补骨脂的潜在肝损伤成分及毒性靶点未被发现。随着系统生物学技术的不断发展,利用网络毒理学方法构建药物性肝损伤和肝损伤预测模型,能够大大降低实验成本,有效提高毒性预测效率,为挖掘潜在毒性成分及相关毒性靶点提供新的工具。为了更系统地阐释补骨脂应用过程中出现的肝损伤的特点,挖掘补骨脂潜在肝损伤成分及相关靶点,进而阐释其毒性机制,该文首先对1962—2021年中国知网、万方、维普、PubMed数据库收录的有关补骨脂肝损伤的文献报道进行整理和统计,分析临床上补骨脂肝损伤的特点和影响因素;进而对文献中报道的补骨脂的物质成分和入血成分进行总结;并对临床前体内、体外实验发现的补骨脂肝损伤机制、靶点、相关成分进行梳理,总结目前已知的补骨脂中可能具有肝损伤的化合物;最后对目前采用网络毒理学构建的补骨脂肝损伤预测模型获取的补骨脂肝损伤成分及靶点预测结果进行总结。从临床肝损伤特点、临床前肝损伤研究、计算机网络预测3方面阐释补骨脂肝损伤发生可能的相关因素,为补骨脂肝损伤研究和风险提示提供参考。Psoraleae Fructus(PF)is a non-toxic Chinese herbal medicine,while the liver injury caused by PF has aroused wide concern in recent years.At present,animal experiments and in vitro studies have been carried out to explore the mechanism,targets,and toxic components of PF in inducing liver injury,which,however,have differences compared with the actual conditions in clinical practice,and there are still some potential hepatotoxic components and targets of PF that have not been discovered.With the continuous progress in systems biology,establishing the drug-induced liver injury model and the liver injury prediction model based on network toxicology can reduce the cost of animal experiments,improve the toxicity prediction efficiency,and provide new tools for predicting toxic components and targets.To systematically explain the characteristics of liver injury in the application of PF and explore the potential hepatotoxic components and targets of PF,we reviewed the related articles published by China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,and PubMed from 1962 to 2021 and analyzed the characteristics and influencing factors of liver injury caused by PF in the patients.Furthermore,we summarized the chemical components of PF and the components entering blood.By reviewing the mechanism,targets,and components of PF in inducing liver injury that were discovered by in vivo and in vitro experiments,we summarized the known compounds in PF that may cause liver injury.Finally,the current methods for building the prediction model of PF-induced liver injury were summarized,and the predicted toxic components and targets were introduced.The possible factors of PF in causing liver injury were explained from three aspects:clinical characteristics,preclinical studies,and computerassisted network prediction,which provide a reference for predicting the risk of PF-induced liver injury.

关 键 词：补骨脂 肝损伤 毒性机制 毒性靶点 网络毒理学 

分 类 号：R2-0[医药卫生—中医学] R22R242R285.5R575.3