疫苗佐剂“益气增免方”组方配伍理论探析  

Compatibility Theory of Yiqi Zengmian Prescription as Vaccine Adjuvant

作　　者：古欣怡 佟琳[2] 唐仕欢[3] 李慧[4] 霍蕊莉[5] GU Xinyi;TONG Lin;TANG Shihuan;LI Hui;HUO Ruili(Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Information on Traditional Chinese Medicine(TCM),China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of TCM Health Industry,China Academy of Chinese Medical Sciences,Beijing 100700,China;China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]中国中医科学院中医药信息研究所,北京100700 [3]中国中医科学院中药研究所,北京100700 [4]中国中医科学院中医药健康产业研究所,北京100700 [5]中国中医科学院,北京100700

出　　处：《中国实验方剂学杂志》2024年第1期208-215,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划“公共安全风险防控与应急技术装备”重点专项新型冠状病毒疫苗科研攻关项目(2022YFC0867600);中国中医科学院中央级公益性科研院所基本科研业务费委托专项(ZZ15-WT-06)。

摘　　要：目的:为防控新型冠状病毒肺炎疫情提供中医药新的防范方案,探讨益气增免方作为一种疫苗佐剂的应用。该方剂由经典的补气剂四君子汤化裁而来,以药性配伍和功效剖析为基础,分析了益气增免方与疫苗的配伍效应及其影响机制。方法:该文章应用《古代经典名方数据库》对益气增免方方剂组成开展了相似度比对研究,并从药性、配伍、功效等不同方面剖析益气增免方的配伍理论基础,分析其与疫苗的配伍效应及其影响机制。结果:中药疫苗佐剂益气增免方作为一种中医药复方,聚焦于肺脾二脏,提升肺脾之气。肺为气之主,机体通过肺脏呼吸新鲜空气,并在肺内交换体内浊气,气在肺中交替循环,保证人体正常的呼吸;脾主运化,是气机升降之枢纽,而气正是代谢功能的具象。通过调节气机、增强气血功能,益气增免方可以增强免疫原性,为增强疫苗免疫效果提供理论依据。结论:益气增免方具有益气健脾,理气燥湿,增强免疫力的功效。通过对疫苗佐剂益气增免方中医理论的深度剖析,结合前期临床及基础实验研究结果,提示益气增免方可能具有增强疫苗接种后的免疫反应诱导和维持免疫记忆,而其是如何能对复杂的免疫调控网络进行有效调理的,还需进一步阐明。Objective:This study explored the application of Yiqi Zengmian prescription as a vaccine adjuvant,aiming to provide a new scheme for the prevention and control of corona virus disease 2019(COVID-19)with traditional Chinese medicine(TCM).By analyzing the compatibility and efficacy,this paper examines the compatibility effect of Yiqi Zengmian prescription,which is modified from the classic tonifying agent SiJunzitang,as a vaccine adjuvant.Method:Using the Database of Ancient Classical Prescriptions,this paper analyzed the composition of Yiqi Zengmian prescription and probed into the theoretical basis for the compatibility of this prescription from the properties,medicine combination,and efficacy.Furthermore,the compatibility effect of this prescription with vaccines was analyzed.Result:As a TCM prescription,Yiqi Zengmian prescription focuses on the lung and spleen and enhances the Qi in the two organs.The lung governs Qi movement.The body breathes fresh air through the lungs and exchanges the turbid gas in the lungs,and the gas circulates alternately in the lungs to ensure the normal breathing of the human body.The spleen governing transportation and transformation is the hub for Qi movement,and Qi is the embodiment of metabolic function.By regulating qi movement and enhancing the functions of Qi and blood,Yiqi Zengmian prescription can enhance the immunogenicity of the vaccine,which provides a theoretical basis for enhancing the immune effects of vaccines.Conclusion:Yiqi Zengmian prescription has the effects of replenishing Qi and invigorating spleen,regulating Qi and drying dampness,and enhancing immunity.The in-depth analysis of the TCM theory of Yiqi Zengmian prescription as a vaccine adjuvant and the results of clinical and laboratory studies suggest that Yiqi Zengmian prescription may enhance the induction of immune response after vaccination and maintain the immune memory.However,the mechanism of Yiqi Zengmian prescription in regulating the complex immune network remains to be elucidated.

关 键 词：疫苗佐剂 益气增免方 新型冠状病毒 组方配伍 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24