川黄柏及其活性成分治疗痛风病作用研究进展  

Pharmacological Effect of Phellodendri Chinensis Cortex and Active Components on Gout:A Review

作　　者：李敏[1,2] 全云云 王婷 李莉[2] 曾瑾[2] 赵军宁[1,2] 毛九州 唐杨帆 尹竹君 LI Min;QUAN Yunyun;WANG Ting;LI Li;ZENG Jin;ZHAO Junning;MAO Jiuzhou;TANG Yangfan;YIN Zhujun(School of Pharmacy,Chengdu University of Traditional Chinese Medicine(TCM),Chengdu 610075,China;Sichuan Academy of Chinese Medicine Sciences,Sichuan Center for Translational Chinese Medicine,Key Laboratory of Biological Evaluation of Quality of TCM,State Administration of TCM,Sichuan Key Laboratory of Translational Chinese Medicine,Sichuan Engineering Technology Research Center of Genuine Regional Drug,Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials,Chengdu 610041,China;Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations,the"Double-First Class"Application Characteristic Discipline of Hunan Province(Pharmaceutical Science),Changsha Medical University,Changsha 410219,China.)

机构地区：[1]成都中医药大学药学院,成都610075 [2]四川省中医药科学院,四川省中医药转化医学中心,国家中医药管理局中药质量生物评价重点研究室,中医药转化医学四川省重点实验室,四川省道地药材形成原理与品质评价工程研究中心,四川省道地药材系统开发工程技术研究中心,成都610041 [3]长沙医学院,新型药物制剂研发湖南省重点实验室,湖南省“双一流”应用特色学科-药学,长沙410219

出　　处：《中国实验方剂学杂志》2024年第1期286-298,共13页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：四川省自然科学基金面上项目(2023NSFSC0669);四川省科技厅省级科研院所基本科研业务专项(A-2021N-Z-3);四川省中医药管理局创新团队专项(2022C009);四川省中医药管理局中药药理学重点学科专项(ZDXK2020-1)。

摘　　要：痛风病是与高尿酸血症、尿酸盐沉积密切相关的代谢性疾病。因其致病机制复杂,高发病率、多并发症和患病年轻化而备受关注。目前西医主要通过降尿酸及抗炎等方式治疗痛风病,但存在严重不良反应和使用禁忌。川黄柏为芸香科植物黄皮树的干燥树皮,具有清热燥湿、泻火除蒸、解毒疗疮等功效。众多研究表明黄柏及其活性成分具有抗炎、镇痛、降尿酸、抗痛风等多种药理活性,具有来源广,安全性高的特点。机制研究发现,黄柏及其活性成分可通过多靶点、多途径防治痛风病,但是缺乏系统、全面的总结与分析。故该文针对川黄柏及其活性成分抗痛风作用机制的相关文献进行分析归纳。分析结果表明,黄柏及其活性成分主要通过降低尿酸水平、抑制炎症反应、改善氧化应激,调节肠道菌群及缓解肾脏损伤等作用机制发挥治疗痛风病的作用,其中以生物碱类成分为代表的活性成分效果尤为显著。该研究在此基础上分析当前研究存在的问题及未来发展趋势,以期为川黄柏抗痛风的物质基础及新药研发提供理论支持与科学依据。Gout is a metabolic disease closely associated with hyperuricemia and urate deposition.Because of the complex pathogenesis,high morbidity,multiple complications,and increasingly young patients,gout has received worldwide attention.Currently,western medicine mainly treats gout by lowering the uric acid level and reducing inflammation,which,however,causes serious adverse reactions and has contraindications.Phellodendri Chinensis Cortex(PCC)is the dried bark of Phellodendron chinense,with the effects of clearing heat,drying dampness,purging fire,detoxifying,and treating sores.Studies have shown that PCC and its active components have anti-inflammatory,pain-relieving,uric acid-lowering,and anti-gout activities,with extensive sources and high safety.PCC and its active components could prevent and treat gout through multitargets and multi-pathways,whereas the systematic review remains to be carried out.Therefore,this paper summarized the pharmacological activities and mechanisms of PCC and its active components in the treatment of gout.The available studies have shown that PCC and its active components exert the anti-gout effect by lowering the uric acid level,reducing inflammation,alleviating oxidative stress,and regulationg intestinal flora,and protecting the kidneys.Particularly,the active components represented by alkaloids contribute obviously to the therapeutic effect of of PCC.Herein,we analyzed the problems and future development of the research on PCC,aiming to provide theoretical support and a scientific basis for the research and development of new drugs against gout.

关 键 词：痛风 川黄柏 活性成分 作用机制 研究进展 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24